Cytotoxic drug conjugates and their delivery to tumor cells
Patent 5087616 Issued on February 11, 1992. Estimated Expiration Date: 
February 11, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 11, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3917824 Immunotoxin conjugate which comprises arsanilic acid, useful for treating malignant tumors, particularly pancreatic cancer Method of producing human epidermal growth factor Pseudomonas exotoxin conjugate immunotoxins Patent #: 4545985 InventorsAssigneeApplicationNo. 082244 filed on 08/06/1987US Classes:514/21, Produced by or extracted from animal tissue514/12, 25 or more peptide repeating units in known peptide chain structure530/342, Mixed anhydride synthesis530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.530/399, Hormones, e.g., prolactin, thymosin, growth factors, etc.530/408, Sulfur containing reactant530/409, Nitrogen containing reactant530/410Oxygen containing reactantExaminersPrimary: Moezie, F. T.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 037/36A61K 037/02 C07K 013/00 Foreign Application Priority Data1986-08-07 EPAbstractA therapeutic composition comprising a chemical conjugatge including a first moiety, other than an immunoglobulin or fragment thereof, such as epidermal growth factor, which preferentially binds to a tumor cell, and is internalized by the cell, and a second moiety linked to the first moiety, and comprising a biodegradable polymeric carrier, such as polyglutamic acid, to which one or more cytotoxic molecules, for instance, daunomycin, are attached. The degradation of the carrier by intracellular enzymes releases a cytotoxic agent, resulting in selective destruction of the tumor cells.Other References
Field of SearchChemical aftertreatment, e.g., acylation, methylation, etc.Hormones, e.g., prolactin, thymosin, growth factors, etc. Sulfur containing reactant Nitrogen containing reactant Oxygen containing reactant Produced by or extracted from animal tissue 25 or more peptide repeating units in known peptide chain structure |
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