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US Patent 5084480 - Pentamidine salts useful in the treatment of pneumocystis carinii pneumonia

US Patent Issued on January 28, 1992
Estimated Patent Expiration Date: Icon_subject July 19, 2009Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Salts of pentamidine, formulations containing such salts and the use of such salts of treatment or prophylaxis of pneumocystis carinii. Pentamidine gluconate and lactate has been discovered and found to have high water solubility while providing potentially less toxic alternatives to pentamidine isethionate, especially for aerosolized administration to patients suffering from acquired immunodeficiency syndrome, AIDS, or AIDS related complex, ARC.

Other References

  • Hawley, Gessner G., The Condensed Chemical Dictionary, Von Nostrand Reinhold Co., New York, 10th Ed., p. 143, (1983)
  • A Chemotherapeutic Comparison of the Trypanocidal Action of Some Aromatic Diamidine Ashley et al., 1942
  • PENTAM™ 300 Package Insert, (no date), p. 120

Inventors

Assignee

Application

No. 383243 filed on 07/19/1989

US Classes:

514/554, Amine addition salt of the acid562/587, Polyoxy562/589Lactic acid per se or salt thereof

Field of Search

562/589, Lactic acid per se or salt thereof562/587, Polyoxy514/554Amine addition salt of the acid

Examiners

Primary: Gray, Bruce

Attorney, Agent or Firm

US Patent References

2204983, 2277861, 2277862, 2410796, 2424325, 2425223, 2449724, 3105853, 4034010, Bis-(meta-amidinophenoxy)-compounds and pharmacologically acceptable acid addition salts thereof
Issued on: 07/05/1977
Inventor: Hamano ,   et al.
4097525, Aromatic amidines as antiviral agents in animals
Issued on: 06/27/1978
Inventor: Kraska ,   et al.
4367231, Method of using octahydro pyrazolo[3,4-g]quinolines
Issued on: 01/04/1983
Inventor: Kornfeld ,   et al.
4501890Trans-( &#b1;)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quino lines
Issued on: 02/26/1985
Inventor: Nichols ,   et al.

Foreign Patent References

  • 729847 GB. 02/19/2010

International Class

A61K 031/205

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