Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide
March 13, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for solid phase-sequencing of nucleic acid fragments Antibody purification process Computer-based method for designing stablized proteins Automatable process for sequencing nucleotide Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides Method for purifying a gene-expression product produced by recombinant DNA technique 48001166 InventorsAssigneeApplicationNo. 322266 filed on 03/13/1989US Classes:703/6, SIMULATING NONELECTRICAL DEVICE OR SYSTEM435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide436/89, Amino acid or sequencing procedure530/344, Separation or purification530/413, Immunological separation or affinity chromatography703/12ChemicalExaminersPrimary: Teska, Kevin J.Attorney, Agent or FirmInternational ClassesG06F 015/42G01N 033/68 AbstractA computer-implemented method for designing at least one anti-peptide sequence having affinity for target peptide or a fragment thereof suitable for synthesizing peptides and micromolecules, assaying for a target peptides, purifying target peptides, and/or preventing proteolyis of a polypeptide includes identification of the members of the amino acid sequence of the target peptide and their anti-sense or hydropathically complementary amino acids and determining the moving average hydropathy for the target and anti-sense members. The resulting lowest hydropathy identifies the anti-sense amino acid sequence for the target peptide. The members of the target peptide amino acid sequence are obtained along with their member-specific hydropathic values with the hydropathic values summed as a moving average. Anti-sense or complementary amino acid members are identified from the moving average information to generate an array of anti-sense amino acid sequences. The hydropathic values of the array of anti-sense amino acids are obtained along with their moving average hydropathic values from which a hydropathic complementary score is obtained with the lowest score identifying the anti-sense amino acid sequence having affinity for the target peptide.Other References
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