Benzothiazine dioxide derivatives
Patent 5081118 Issued on January 14, 1992. Estimated Expiration Date: 
April 26, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 26, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3591584 3892740 Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor Process for preparing 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives and intermediates therefor Benzothiazine dioxide derivatives Patent #: 4829062 InventorsApplicationNo. 460121 filed on 04/26/1990US Classes:514/226.5, One of the cyclos is a 1,2-thiazine (e.g.,1,2-benzothiazines, etc.)544/49Benzothiazines (including hydrogenated)ExaminersPrimary: Scalzo, Catherine S. KilbyAttorney, Agent or FirmInternational ClassesC07D 279/02A61K 031/54 AbstractA series of novel oxyethyl derivatives of certain selected enolic oxicam compounds are disclosed, including certain novel oxyethyl derivatives of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (piroxicam). These particular compounds are useful in therapy as prodrug forms of the known anti-inflammatory and analgesic oxicams. Said oxyethyl derivatives of enoic oxicam compounds like piroxicam are of the formulae: ##STR1## wherein R1 is hydrogen, methyl, fluorine or chlorine, and R2 is hydrogen or --COOR3 wherein R3 is alkyl having from one to eight carbon atoms. |
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