Method and device for producing a controllable and reproducible temperature gradient and use thereof
Patent 5066377 Issued on November 19, 1991. Estimated Expiration Date: 
June 29, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 29, 2010. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2888392 3402118 3801467 Method and apparatus for heating and/or cooling objects simultaneously at different preselected temperatures Patent #: 4679615 InventorsAssigneeApplicationNo. 545111 filed on 06/29/1990US Classes:204/466, Using slab gel204/616Slab gelExaminersPrimary: Niebling, John F.Assistant: Starsiak, John S. Jr. Attorney, Agent or FirmInternational ClassesG01N 027/26B01D 057/02 Foreign Application Priority Data1986-07-04 DEAbstractA method and a device for producing a controllable and reproducible temperature gradient in a predetermined direction of heat-conducting plates for the separation of mixtures of substances in sheet-shaped separating media wherein one edge of a plate is heated by means of one or more controllable heating means and the opposite edge of the plate is cooled by one or more controllable cooling means. In this way, the energy flows through the heating means and of the cooling means are greater than the energy flow across the plate. The method and device are suitable for separating mixtures of substances wherein at least one component undergoes a thermal conversion within the temperature range of the temperature gradient. Therefore, they are suitable for the detection of and differentiation between viroids, satellite RNAs, viruses containing double-strand or circular nucleic as well as for the analysis of protein-nucleic acid complexes and for the analysis of mutations.Other References
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