Sustained-release formulations

Patent 5055306 Issued on October 8, 1991. Estimated Expiration Date:

October 20, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3131123

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Inventors

Assignee

APS Research Limited

Application

No. 260415 filed on 10/20/1988

US Classes:

424/482, Containing solid synthetic polymers424/466, Effervescent424/480Cellulose or derivative

Examiners

Primary: Page, Thurman K.
Assistant: Hulina, Amy

Attorney, Agent or Firm

Spencer & Frank

Foreign Patent References

0052076 EP. 11/12/1980
0207041 EP. 06/12/1986
0255404 EP. 07/12/1987
2086725 GB. 11/12/1981

International Classes

A61K 009/32
A61K 009/46
A61K 007/36

Foreign Application Priority Data

1987-10-22 GB

Abstract

A granular sustained-release formulation of a pharmacologically active substance presented in the form of a tablet, said tablet comprising sufficient granules to provide a predetermined dose or number of doses of the pharmacologically active substance and effervescent or water-dispersible ingredients, each of said granules having a diameter of preferably between 0.5 and 2.5 mm and comprising:a) a core comprising one or more pharmacologically active substances and preferably one or more excipients; andb) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and from 20 to 70 parts of a water soluble hydroxylated cellulose derivative, the weight of the coating being from 2 to 25% of the weight of the core.A method for preparing this effervescent of water-dispersible tablet formulation is also provided. Such formulations enable large dosages in sustained-release form to be more easily administered to patients.