U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Novel liposome composition for the treatment of interstitial lung diseases

Patent 5049389 Issued on September 17, 1991. Estimated Expiration Date: Icon_subject December 1, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Compositions containing aqueous dispersions of lipid spheres
Patent #: 4217344
Issued on: 08/12/1980
Inventor: Vanlerberghe ,   et al.

Drug delivery method and inhalation device therefor
Patent #: 4484577
Issued on: 11/27/1984
Inventor: Sackner ,   et al.

Small particle aerosol generator for treatment of respiratory disease including the lungs
Patent #: 4649911
Issued on: 03/17/1987
Inventor: Knight ,   et al.

Aerosol inhalation apparatus
Patent #: 4823784
Issued on: 04/25/1989
Inventor: Bordoni ,   et al.

Pharmaceutical compositions
Patent #: 4849227
Issued on: 07/18/1989
Inventor: Cho

Compositions comprising aqueous dispersions of lipid spheres
Patent #: 4897308
Issued on: 01/30/1990
Inventor: Vanlerberghe, et al.

Novel liposome composition for sustained release of steroidal drugs in lungs Patent #: 4906476
Issued on: 03/06/1990
Inventor: Radhakrishnan

Inventor

Assignee

Application

No. 444738 filed on 12/01/1989

US Classes:

424/450, Liposomes264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)424/434Mucosal (e.g., nasal, etc.)

Examiners

Primary: Page, Thurman K.
Assistant: Kishore, G. S.

Attorney, Agent or Firm

Foreign Patent References

  • WO88/06881 WO. 09/13/1988
  • WO88/06882 WO. 09/13/1988
  • WO88/06883 WO. 09/13/1988

International Classes

A61K 037/22
A61F 013/00
B01J 013/02

Abstract

A non-conventional lipid particle formulation for the sustained release and delivery of steroids into deep lung is disclosed. The formulation provides prolonged release of the drug, improved therapeutic ratio, lower toxicity, reduced systemic side effects, and stability for several months. The formulation is in particular suitable for treatment of interstitial lung diseases.

Other References

  • J. Microencapsulation 4:189-200 (1987), Inhalation Study Techniques, pp. 9-31, R. F. Phalen, Editor, CRC Press (1984)
  • New Eng. J. Med. 315:870 (1986)
  • Amer. Rev. Resp. Dis. 41:A349 (1988)
  • Eur. Resp. J. 2:218 (1988)
  • Eur. J. Resp. Dis. 68:19 (1988)
  • Biochemistry 17:3759 (1978)
  • Biochim. Biophsy. Acta 691:227 (1982
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