Mucoadhesive carrier for delivery of therapeutical agent
Patent 5047244 Issued on September 10, 1991. Estimated Expiration Date: 
September 10, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 10, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3551556 3911099 Method comprising transdermal and buccal treatment of angina Sustained-release preparation applicable to mucous membrane in oral cavity Patent #: 4740365 InventorsAssigneeApplicationNo. 202662 filed on 06/03/1988US Classes:424/435, Mouth424/434, Mucosal (e.g., nasal, etc.)424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/448, Pressure sensitive adhesive means424/484, Matrices424/486, Synthetic polymer514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/182, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/224.2, Polycyclo ring system having the six-membered hetero ring as one of the cyclos (e.g., 1,3- and 1,4- benzothiazines, etc.)514/356, C=O in a C(=O)O group (e.g., nicotinic acid, etc.)514/653Hydroxy, bonded directly to carbon, attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding (e.g., beta hydroxy phenethylamines, etc.)ExaminersPrimary: Page, Thurman K.Assistant: Spear, James M. Attorney, Agent or FirmForeign Patent References
International ClassesA61F 013/00A61K 009/26 AbstractA mucoadhesive carried suitable for a therapeutic agent is disclosed. This carrier allows controlled release of the therapeutic agent via mucosal tissue. The mucoadhesive carrier comprises a Monolithic polymer matrix that is anhydrous but hydratable, and amorphous fumed silica. The silica enhances the mucoadhesive properties of the carrier. An optional water-insoluble barrier film or layer can be secured to the polymer matrix to provide a non-adhering face. | |
