Neomorphogenesis of cartilage in vivo from cell culture
April 17, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesCell culture method Cell culture propagation apparatus Anti-invasion factor containing cultures Bone-equivalent and method for preparation thereof Regeneration of living tissues by growth of isolated cells in porous implant and product thereof Inductive collagen based bone repair preparations Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites Method of producing prostheses for replacement of articular cartilage and prostheses so produced Repair of cartilage and bones Porous structure of polytetrafluoroethylene and process for production thereof InventorsAssigneeApplicationNo. 339155 filed on 04/17/1989US Classes:424/422, Implant or insert424/548, Derived from musculoskeletal system, other than cardiac muscle (e.g., cartilage, muscle, etc.)514/21, Produced by or extracted from animal tissue530/840, Bones; tendons; teeth; cartilage623/10, EAR OR NOSE PROSTHESIS623/919BoneExaminersPrimary: Cannon, Alan W.Attorney, Agent or FirmForeign Patent References
International ClassesA61F 002/28A61F 002/18 C07C 245/00 A61K 037/00 AbstractMethods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an adequate cell volume and density has developed for the cells to survive and proliferate in vivo. One advantage of the matrices is that they can be cast or molded into a desired shape, on an individual basis, so that the final product closely resembles a patient's own ear or nose. Alternatively, flexible matrices can be used which can be manipulated at the time of implantation, as in a joint, followed by remodeling through cell growth and proliferation in vivo. The cultured cells can also be maintained on the matrix in a nutrient media for production of bioactive molecules such as angiogenesis inhibiting factor.Other References
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