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US Patent 5036857 - Noninvasive diagnostic system for coronary artery disease

US Patent Issued on August 6, 1991
Estimated Patent Expiration Date: Icon_subject October 26, 2009Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A method and system for non-invasively detecting Coronary Artery Disease. The method comprises analyzing the diastolic heart sounds detected from a patient's chest cavity during the diastolic portion of the heart cycle in order to identify a low level auditory component associated with turbulent blood flow in partially occluded coronary arteries. These diastolic heart sounds are modeled using advanced signal processing techniques such as Autoregressive (AR), Autoregressive Moving Averaging (ARMA) and Eigenvector methods, so that the presence of such an auditory component may be reliably indicated even under high noise conditions. The system includes an acoustic transducer, pulse sensor device, signal processor means and a diagnostic display. Additionally, the system includes a controller for automatically sequencing data collection, analysis and display stages, therefore requiring a minimum of operator interaction. The system further discloses a piezoelectric type low mass accelerometer for use as an acoustic transducer providing higher sensitivity at the high frequencies necessary for detecting coronary artery disease, specifically between 300 to 1200 Hz. In addition, the system discloses a method for automatically identifying and isolating a diastolic segment of a heart sound recording through a "window" placement technique. A window is placed relative to the second heart sound and various criteria are implemented to evaluate the recording for artifacts, i.e., data due to breath sounds, stomach growls, external ambient noise.

Other References

  • David W. Mortara, Ph.D., Raymond E. Ideker, M.D., James J. Bailey, M.D.; Computerized Interpretation of the Electrocardiogram; Jun. 1984; Reference pp. 5-17 (James Bailey, M.D., Editor, Jun. 1984)
  • Akay et al, "Analysis of Diastolic Heart Sounds Before and After Angioplasty", IEEE, EMBS 10th Int'l. Conf., Nov. 1988
  • Akay et al, "Autoregressive Modeling of Diastolic Heart Sounds", IEEE, EMBS 10th Int'l. Conf. Nov. 1988
  • Ortiz, M., "Acoustical Noninvasive Diagnosis of Coronary Artery Disease", Proc. of 13th Ann. NE. Bioeng. Conf., 1987
  • Ortiz, M., "Non-Invasive Acoustical Diagnosis of Coronary Artery Disease", Thesis, May, 1987
  • Ortiz et al, "Coronary Artery Disease: Noninvasive Diagnosis", 40th ACEMB Proceedings, Sep. 1987
  • Vermarien et al, "The Recording of Heart Vibrations: A Problem of Vibration in Measurement . . . ", Med. & Bioeng. & Comp., Mar. 1984
  • Semmlow et al, "Coronary Artery Disease--Correlates Between Diastolic Auditory . . . ", IEEE Trans. in BME, vol. 30, Feb. 1983
  • Schwartz et al, "Improved Phonocardiogram System Based on Acoustic Impedance Matching", Am. J. Physiol., 1980
  • Semmlow et al, "Non-Invasive Diagnosis of Coronary Artery Disease by Enhanced Coronary . . . ", IEEE Frontiers of Eng. in Health, 1982
  • Kosugi, "Detection and Analysis of Cranial Bruit", IEEE Transactions on BME, vol. BME-34, No. 3, Mar. 1987
  • Makhoul, "Linear Prediction: A Tutorial Review", Proceed. of the IEEE, vol. 63, No. 4, Apr. 1975
  • Fischer et al, "Comparative Evaluation of Cardiac Microphones", IEEE EMBS 10th Int'l Conf., Nov. 198

Inventors

Application

No. 426770 filed on 10/26/1989

US Classes:

600/528, Detecting heart sound600/493Electric signal generated by sensing means responsive to pulse or Korotkoff sounds

Examiners

Primary: Jaworski, Francis J.
Assistant: Manuel, George

Attorney, Agent or Firm

US Patent References

3528297, 4220160, Method and apparatus for discrimination and detection of heart sounds
Issued on: 09/02/1980
Inventor: Kimball ,   et al.
4446873, Method and apparatus for detecting heart sounds
Issued on: 05/08/1984
Inventor: Groch ,   et al.
4467236, Piezoelectric acousto-electric generator
Issued on: 08/21/1984
Inventor: Kolm ,   et al.
4493326, Automatic blood pressure system with servo controlled inflation and deflation
Issued on: 01/15/1985
Inventor: Hill ,   et al.
4546777, Heart sound detector and synchronization for diagnostics
Issued on: 10/15/1985
Inventor: Groch ,   et al.
4549552, Heart sound detector and cardiac cycle data are combined for diagnostic reliability
Issued on: 10/29/1985
Inventor: Groch ,   et al.
4649930, Apparatus for beat buffering techniques varified by arrhythmias detection for stopaction frames of cardiac function
Issued on: 03/17/1987
Inventor: Groch ,   et al.
4672976, Heart sound sensor
Issued on: 06/16/1987
Inventor: Kroll
4680708, Method and apparatus for analyzing electrocardiographic signals
Issued on: 07/14/1987
Inventor: Ambos ,   et al.
4720866, Computerized stethoscopic analysis system and method
Issued on: 01/19/1988
Inventor: Elias ,   et al.
4781200, Ambulatory non-invasive automatic fetal monitoring system
Issued on: 11/01/1988
Inventor: Baker
4784154, Interference resistant biomedical transducer
Issued on: 11/15/1988
Inventor: Shirley ,   et al.
4792145, Electronic stethoscope system and method
Issued on: 12/20/1988
Inventor: Eisenberg ,   et al.
4803996, Cardiovascular monitor
Issued on: 02/14/1989
Inventor: Peel ,   et al.
4862361Methods and apparatus for monitoring cardiovascular regulation using heart rate power spectral analysis
Issued on: 08/29/1989
Inventor: Gordon ,   et al.

International Class

A61B 005/02

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