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AbstractMonoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as therapeutic methods employing the cell suspensions.Other References
| InventorAssigneeApplicationNo. 580337 filed on 09/07/1990US Classes:435/2, MAINTAINING BLOOD OR SPERM IN A PHYSIOLOGICALLY ACTIVE STATE OR COMPOSITIONS THEREOF OR THEREFOR OR METHODS OF IN VITRO BLOOD CELL SEPARATION OR TREATMENT435/7.21, Animal cell435/7.23, Tumor cell or cancer cell435/7.24, Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)436/548Monoclonal antibodyField of Search435/2, MAINTAINING BLOOD OR SPERM IN A PHYSIOLOGICALLY ACTIVE STATE OR COMPOSITIONS THEREOF OR THEREFOR OR METHODS OF IN VITRO BLOOD CELL SEPARATION OR TREATMENT436/548Monoclonal antibodyExaminersPrimary: Moskowitz, MargaretAssistant: Cunningham, T. Attorney, Agent or FirmUS Patent References4364932, Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing sameIssued on: 12/21/1982 Inventor: Kung , et al.4364937, Monoclonal antibody to a human T cell antigen and methods of preparing same Issued on: 12/21/1982 Inventor: Kung , et al.4381292, Anti-human T-lymphocyte monoclonal antibody Issued on: 04/26/1983 Inventor: Bieber , et al.4381295, Monoclonal antibody to human helper T cells and methods of preparing same Issued on: 04/26/1983 Inventor: Kung , et al.4443427, Monoclonal antibody Issued on: 04/17/1984 Inventor: Reinherz , et al.4582797, Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins Issued on: 04/15/1986 Inventor: Trowbridge4624925, Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigens, antibody, and methods Issued on: 11/25/1986 Inventor: Kung , et al.4710457Monoclonal antibody for human hematopoietic glycoproteins and method Issued on: 12/01/1987 Inventor: Dupont , et al. International ClassesA01N 001/02A61M 037/00 C12Q 001/00 G01N 033/53 |