U.S. patents available from 1976 to present.
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Heparin fragments as inhibitors of smooth muscle cell proliferation

Patent 5032679 Issued on July 16, 1991. Estimated Expiration Date: Icon_subject August 31, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them Patent #: 4401662
Issued on: 08/30/1983
Inventor: Lormeau ,   et al.

Inventors

Assignee

Application

No. 400661 filed on 08/31/1989

US Classes:

536/21, Heparin or derivative536/17.2, Nitrogen containing536/17.5, Sulfur containing (e.g., methylthiolincosaminide, etc.)536/17.9, Nitrogen in aglycone moiety536/124Processes

Examiners

Primary: Griffin, Ronald W.
Assistant: White, Everett

Attorney, Agent or Firm

International Classes

C08B 037/00
C07H 005/00
A61K 031/00

Abstract

A glycosaminoglycoside (GAG) composition predominantly of tetrasacchardie units derived from heparin/heparan sulfate has enchanced activity in preventing the proliferation of smooth muscle cells. This GAG preparation is useful in the treatment of diseases characterized by unwanted smooth muscle cell proliferation and activity.

Other References

  • Casu, (1985) "Structure and Biological Activity of Heparin" in Advances in Carbohydrate Chemistry and Biochemistry 43:51-134
  • Castellot et al., (1986) Journal of Cell Biology 102:1979-1984
  • Benitz et al., (1986) Journal of Cellular Physiology 127:1-
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