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Activity against carcinoma and method for the treatment of carcinoma

Patent 5032610 Issued on July 16, 1991. Estimated Expiration Date: Icon_subject November 21, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Application

No. 275091 filed on 11/21/1988

US Classes:

514/467, Only two ring oxygens in the hetero ring which is not a polycyclo ring system (e.g., dioxolane, etc.)514/474Ascorbic acid or derivative (e.g., vitamin C, etc.)

Examiners

Primary: Goldberg, Jerome D.

Attorney, Agent or Firm

Foreign Patent References

  • 148094 EP 07/13/1985
  • 0283139A2 EP 09/13/1988

International Classes

A61K 031/335
A61K 031/34

Abstract

The use of L-ascorbic acid, or a pharmaceutically acceptable salt thereof, in combination with 5,6-O-benzylidene-L-ascorbic acid, or 5,6-O-benzylidene-L-ascorbic acid deuterated at least at the 1-position of the aldehyde group of the benzylidene moiety, or a pharmaceutically acceptable salt of such acids, results in a synergistically enhanced cytotoxicity on human carcinoma cells.

Other References

  • Cameron et al., Cancer Research 39, 663-681, Mar. 197
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