N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
Patent 5028610 Issued on July 2, 1991. Estimated Expiration Date: 
July 2, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 2, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesBenzhydrylpiperazine derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same Antianaphylactic and antibronchospastic piperazinyl-(N-substituted phenyl)carboxamides, compositions and use N -(substituted)--(3,5-dialkyl-4-hydroxyphenyl)-,-disu bstituted acetamides, and composition stabilized therewith Benzhydrylpiperazines pharmaceutical compositions thereof and method of use Patent #: 4868184 InventorsAssigneeApplicationNo. 167354 filed on 03/14/1988US Classes:514/255.03, Carbocyclic ring bonded directly to the piperazine ring540/553, The hetero ring contains plural nitrogens (e.g., 1,3-diazepines, etc.)540/575, The nitrogens are in the 1,4-positions of the hetero ring544/238, 1,2-diazines which contain an additional hetero ring544/295, Plural diazine rings544/357, Plural diazine rings544/370, 1,3-diazole ring (including hydrogenated)544/384, Chalcogen bonded directly to piperazine ring carbon544/385, Plural chalcogens bonded directly to piperazine ring carbons544/396, Plural carbocyclic rings bonded directly to the same acyclic carbon544/397Chalcogen bonded directly to the carbonExaminersPrimary: Ivy, C. WarrenAssistant: Turnipseed, James H. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/495C07D 241/04 Foreign Application Priority Data1987-03-18 JPAbstractCompounds of formula (I):A--M--B-- (I)(in which: M represents a saturated heterocyclic group having from 5 to 7 ring atoms of which 2 are nitrogen atoms, said group being unsubstituted or being substituted at any of its carbon atoms by C1 -C6 alkyl and/or oxo substituents: A represents a halo-substituted benzhydryl substituent; and B represents certain specific substituted alkyl groups) and salts thereof are valuable for the treatment and prophylaxis of disorders arising from circulatory problems, especially those affecting the brain. They may be prepared by reacting a compound of formula A--M--H with a halo or acyloxy derivative corresponding to the alkyl substituent B which it is desired to introduce.Other References
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