U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Amphetamine-protein complex as immunogen for obtaining antibodies specific to methamphetamine

Patent 5026827 Issued on June 25, 1991. Estimated Expiration Date: Icon_subject August 31, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3878187

Phenethylamine antigenic conjugates, their preparation, antibodies and use Patent #: 3996344
Issued on: 12/07/1976
Inventor: Gross

Inventors

Assignee

Application

No. 401247 filed on 08/31/1989

US Classes:

530/405, Nitrogen containing reactant436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN530/363, Serum albumin, e.g., BSA, HSA, etc.530/380, Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc.530/409Nitrogen containing reactant

Examiners

Primary: Russel, Jeffrey E.
Assistant: Kim, Harry C.

Attorney, Agent or Firm

Foreign Patent References

  • 0311383 EP. 10/13/1988

International Classes

C07K 017/02
A61K 039/385

Foreign Application Priority Data

1988-09-02 JP

Abstract

A N-(4-aminobutyl)amphetamine-protein complex has been synthesized to be used as an immunogen to prepare an antibody having a high affinity to methamphetamine. The antibody prepared by the use of the complex has 1,000 times the affinity to methamphetamine as that of an antibody prepared by the use of N-(4-aminobutyl)methamphetamine-protein complex as an immunogen.

Other References

  • Cheng et al. (1973) Febs Letts. 36(3):339-342
  • Chem. Abstract 108(15): 126018d, Yoshii et al. (1987) Nippon Hoigaku Zasshi 41(4):342-346
  • Usagawa et al. (1989) J. Immunol. Methods 119:111-115
  • Chem. Abstract CA Registry File Sheet Showing RN 113349-76-1
  • English translation copy of Yoshii et al. (1987) Nippon Hoigaku Zasshi 41(4):342-346
  • Biological Abstracts, vol. 71, No. 7, 1981, Abstract No. 48539, Biological Abstracts, Inc., Philadelphia, PA, U.S.A; S. Inayama, et al.: "A Rapid and Simple Screening Method for Methamphetamine in Urine by Radioimmunoassay Using a Iodine-152-Labeled Methamphetamine Derivative"
  • Clinical Chemistry, vol. 35, No. 9, Sept. 1989, pp. 1998-1999; G. F. Grinstead: "Ranitidine and High Concentrations of Phenylpropanolamine Cross React in the EMIT Monoclonal Amphetamine/Methamphetamine Assay"
  • Clinical Chemistry, vol. 33, No. 6, 1987, p. 1080; N. R. Badcock, et al.: "Benzathine Interference in the EMIT(R)stTM Urine Amphetamine Assay
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