Patent 5024998 Issued on June 18, 1991. Estimated Expiration Date: December 11, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/1.85, Halogen424/94.1, ENZYME OR COENZYME CONTAINING514/58, Dextrin or derivative514/777, Carbohydrate or lignin, or derivative514/937, DISPERSION OR EMULSION536/103Dextrin or derivative
Aqueous parenteral solutions of drugs which are insoluble or only sparingly soluble in water and/or which are unstable in water, combined with cyclodextrin selected from the group consisting of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of ଲ- and γ-cyclodextrin, provide a means for alleviating problems associated with drug precipitation at the injection site and/or in the lungs or other organs following parenteral administration.
Other References
Chemical Abstracts, 110, 101775b (Abstract of Japanese Kokai 88/218,663, published Sep. 12, 1988)
Yoshida et al., International Journal of Pharmaceutics, 46, 1988, 217-222
Koizumi et al., Chem. Pharm. Bull., 35(8), 3413-3418 (1987)
Okada et al., Chem. Pharm. Bull., 36(6), 2176-2185 (1988)
Yamamoto et al., in International Journal of Pharmaceutics, 49, 163-171 (1981)
Brewster et al., J. Pharm. Sci., vol. 77, No. 11, Nov. 1988, 981-985
Brewster et al., in Proceedings of the Fourth International Symposium on Cyclodextrins, Munich, 20th-22nd Apr., 1988, pp. 399-404, Kluwer Academic Publishers, Dordrecht, NL
Pitha et al., in Controlled Drug Delivery, ed. S. D. Bruck, vol. I, CRC Press, Boca Raton, Fla., 125-148 (1983)
Uekama, Pharm. Int., Mar. 1985, 61-65
Pitha, Journal of Inclusion Phenomena 2, 477-485 (1984)
Fenyvesi et al., Chem. Pharm. Bull. 32 (2), 665-669 (1984)
Uekama et al., International Journal of Pharmaceutics, 23, 35-42 (1985)
Matsuyama et al., Drug Development and Industrial Pharmacy, 13(15), 2687-2691 (1987)
Pitha et al., International Journal of Pharmaceutics, 29, 73-82 (1986)
Uekama et al., in CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 3(1), 1-40 (1987)
Uekama, in Topics in Pharmaceutical Sciences, 1987, eds. D. D. Breimer & P. Speiser Publishers, B.V. (Biomedical Division), 181-194 (1987)
Pagington, Chemistry in Britain, 455-458 (May 1987)
Carpenter et al., The Journal of Pediatrics, III, 507-512 (Oct. 1987)
Estes et al. in Biological Approaches to the Controlled Delivery of Drugs, ed. R. L. Juliano, Annals of the New York Academy of Sciences, vol. 907, 1987, 334-33
December 11, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
