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US Patent 5011692 - Sustained pulsewise release pharmaceutical preparation
US Patent Issued on April 30, 1991
Estimated Patent Expiration Date:
April 30, 2008Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
April 30, 2008Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractThe invention relates to sustained pulsewise release pharmaceutical preparation which comprices drug-containing polymeric material layers (layers A) and polymeric material layers containing the drug in question only in a slight amount or free of the drug (layers B) disposed alternatingly, with the whole surface extending in the direction perpendicular to the layer plane being coated with a polymeric material which is insoluble in water or scarcely soluble in water (polymeric material C).This pharmaceutical preparation of this invention is designed so that active ingredients which should desirably be released pulsewise can be released therefrom in a pulse-like and clinically significant manner and thereby the pharmacological effects of said active ingredients can be maintained for a prolonged period of time.Other References
| InventorsAssigneeApplicationNo. 946158 filed on 12/23/1986US Classes:424/426, Errodable, resorbable, or dissolving424/425, Diffusion barrier is matrix424/484, Matrices424/485, Natural gums, resin or latex424/486Synthetic polymerField of Search424/484, Matrices424/485, Natural gums, resin or latex424/486, Synthetic polymer424/425, Diffusion barrier is matrix424/426, Errodable, resorbable, or dissolving604/892.1Osmotic or diffusion pumped device or systemExaminersPrimary: Lovering, Richard D.Assistant: Covert, John M. Attorney, Agent or FirmUS Patent References4217898, System with microporous reservoir having surface for diffusional delivery of agentIssued on: 08/19/1980 Inventor: Theeuwes4359483, Process for producing a multi-layered slow release composite Issued on: 11/16/1982 Inventor: Kaetsu , et al.4439196, Osmotic drug delivery system Issued on: 03/27/1984 Inventor: Higuchi4559054, Rate-controlled drug release system Issued on: 12/17/1985 Inventor: Bruck4564364, Active agent dispenser Issued on: 01/14/1986 Inventor: Zaffaroni , et al.4627850, Osmotic capsule Issued on: 12/09/1986 Inventor: Deters , et al.4663147Disc-like sustained release formulation Issued on: 05/05/1987 Inventor: DePrince Foreign Patent References
International ClassA61F 002/00Foreign Application Priority Data1985-12-28 JP |
