U.S. patents available from 1976 to present.
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Composition and method for administration of pharmaceutically active substances

Patent 5011678 Issued on April 30, 1991. Estimated Expiration Date: Icon_subject February 1, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Drug administration
Patent #: 4548922
Issued on: 10/22/1985
Inventor: Carey ,   et al.

Drug administration
Patent #: 4746508
Issued on: 05/24/1988
Inventor: Carey ,   et al.

High-encapsulation liposome processing method
Patent #: 4752425
Issued on: 06/21/1988
Inventor: Martin ,   et al.

Insulin administration using methyl and propyl paraben Patent #: 4789660
Issued on: 12/06/1988
Inventor: Enever ,   et al.

Inventors

Assignee

Application

No. 305520 filed on 02/01/1989

US Classes:

424/45, Organic pressurized fluid514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/3, Insulin or derivative514/171, With additional active ingredient514/808, CALCITONIN OR DERIVATIVES514/866, DIABETES514/922, SIDE EFFECT REDUCTION BY INCORPORATION OF A SECOND DESIGNATED INGREDIENT514/947, Topical application514/951, POWDERS, GRANULES OR PARTICLES OF SPECIFIED MESH OR PARTICLE SIZE514/958, FOR SMOKING OR INHALING514/975CHARACTERIZED BY THE DESIGNATED SURFACTANT USED

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

Foreign Patent References

  • 0200383 EP 12/13/1986
  • 0257956 EP 03/13/1988
  • 360340 EP. 03/13/1990
  • 261096 DD 10/13/1988
  • 60-161924 JP 08/13/1985
  • 63-211237 JP 09/13/1988
  • 8707504 WO 12/13/1987
  • 8800829 WO 02/13/1988
  • 8801864 WO 03/13/1988
  • 2193891 GB 02/13/1988

International Classes

A61K 009/12
A61K 009/14
A61K 037/02

Abstract

Pharmaceutically active substances are administered in aerosol form by applying to a mucosal surface of the body a composition comprising a medically effective amount of a pharmaceutically active substance, a biocompatible amphiphilac steroid and a bicompatible (hydro/fluoro)carbon propellant.

Other References

  • Ayer, Antiseptic, 51:1161-1167 (1954)
  • Govinda-Rao, Indian J. Physiol. Pharmacol., 3:161-167 (1959)
  • Lee et al., J. Pharm. Sci., 65(4):567-572 (1976)
  • Wigley et al., Diabetes, 20:552-556 (1971)
  • Yalow et al., Methods Biochem. Anal., 12:69-96 (1968)
  • G. S. M. J. E. Duchateau et al., Int. J. Pharm., 39: 87-91 (1987)
  • J. P. Longenecker et al., J. Pharm. Sci., 76 (5): 351-355 (1987)
  • W. A. Lee et al., "Intranasal Bioavailability of Insulin Powder Formulations . . . ", submitted to J. Pharm. Sci., in press
  • Longenecker et al, C.A. 107:83791k (1987)
  • Duchateau et al, C.A. 107:242511n (1987)
  • Su et al, C.A. 106:162571w (1986) of EP 200383, Dec. 10, 1986
  • Ueda et al, C.A. 104:10621h (1986) of JP 60/161924, Aug. 23, 1985
  • Martin et al, C.A. 110:121402r (1989) of PCT WO88/01,864, Mar. 24, 198
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