Indolone derivatives, their preparation and their application in therapy
Patent 5010079 Issued on April 23, 1991. Estimated Expiration Date: 
August 2, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
August 2, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3188313 3362956 3732248 Piperazinyl-heterocyclic compounds Patent #: 4883795 InventorsAssigneeApplicationNo. 388373 filed on 08/02/1989US Classes:514/253.05, Isoquinolines (including hydrogenated)514/253.09, Five-membered nitrogen hetero ring attached directly or indirectly to the piperazine ring by nonionic bonding514/254.09, Indole ring system (including hydrogenated) attached directly or indirectly to the piperazine ring by nonionic bonding544/360, Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.)544/362, The additional six-membered hetero ring is one of the cyclos in a bicyclo ring system544/373, The five-membered hetero ring is one of the cyclos in a bicyclo ring system548/485, Plural chalcogens bonded directly to ring carbons of the five-membered hetero ring (e.g., isatins, etc.)548/486The chalcogen is bonded directly to a ring carbon of the five-membered hetero ring which is adjacent to the ring nitrogen (e.g., 2-indolinones, etc.)ExaminersPrimary: Shah, Mukund J.Assistant: Bernhardt, F. Attorney, Agent or FirmInternational ClassesC07D 401/06C07D 403/06 A61K 031/47 A61K 031/495 Foreign Application Priority Data1988-08-03 FRAbstractAn indolone derivative is useful for the treatment of anxiety, depression and schizophrenia and is a 5HT1A agonist and 5HT2 antagonist, which is a compound of formula (I): ##STR1## in which R1 is a hydrogen or halogen atom or a (C1-4)alkyl radical,R2 is a hydrogen atom or a (C1-4)alkyl radical,R3 is a hydrogen atom, a (C1-4)alkyl radical or an S-(C1-4) alkyl radical; andR4 is a phenyl, chlorophenyl, naphthyl, 7-methoxy-1-naphthyl, 6-methoxy-1-indanyl, 2-methoxy-6-pyridyl, 3-methoxy-2-pyridyl, isoquinolyl, 7-methoxy-1-isoquinolyl, 7-methoxy-1,2,3,4-tetrahydro-1-naphthyl or 7-fluoro-1-naphthyl radical;or a pharmaceutically acceptable acid addition salt thereof.Other References
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