Patent References 3870791 Diphenylpropylamino-pyridine compounds useful as medicines Compositions and methods of lowering intraocular pressure in the hypertensive mammalian eye Method of reducing intraocular pressure and treating glaucoma using corynanthine Biodegradable ocular implants Patent #: 4853224 InventorApplicationNo. 318753 filed on 03/03/1989US Classes:424/422, Implant or insert424/423, Surgical implant or material424/427, Ocular424/428Bioerrodable, resorbable, or dissolvingExaminersPrimary: Page, Thurman K.Attorney, Agent or FirmInternational ClassA61K 009/00AbstractQuick miosis with 24 hour control of intraocular pressure of patients undergoing extracapsular cataract extraction surgery is achieved by applying to the eyes of the patient during surgery acetylcholine as a first miotic agent and carbachol as a second miotic agent. Acetylcholine provides quick miosis while carbachol enhances the miotic effect while providing post-surgery control of intraocular pressure. The two miotic agents can be dissolved in a common saline carrier. The two agents can be combined in a unit dosage package by disposing acetylcholine in powder form in a first compartment and a solution of carbachol in a second compartment. The combined miotic agent of the invention is especially useful when substances which raise IOP such as viscoelastic agents are used during ocular surgery and/or with sensitive patients who enter the surgery with elevated pressure such as those suffering from glaucoma. | |