Therapeutic and diagnostic methods using soluble T cell surface molecules

Patent 5006459 Issued on April 9, 1991. Estimated Expiration Date:

April 9, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Immunometric assays using monoclonal antibodies
Patent #: 4376110
Issued on: 03/08/1983
Inventor: David , et al.

Soluble interleukin-2 receptor as a disease indicator and a method of assaying the same Patent #: 4707443
Issued on: 11/17/1987
Inventor: Nelson , et al.

Inventors

Assignee

T Cell Sciences, Inc.

Application

No. 020819 filed on 03/02/1987

US Classes:

435/5, Involving virus or bacteriophage435/7.23, Tumor cell or cancer cell435/7.24, Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)435/810, PACKAGED DEVICE OR KIT435/975, KIT436/501, BIOSPECIFIC LIGAND BINDING ASSAY436/506, FOR PREEXISTING IMMUNE COMPLEX OR AUTO-IMMUNE DISEASE436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/536, INVOLVING IMMUNE COMPLEX FORMED IN LIQUID PHASE436/548, Monoclonal antibody436/811, TEST FOR NAMED DISEASE, BODY CONDITION OR ORGAN FUNCTION436/813, Cancer530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/806ANTIGENIC PEPTIDES OR PROTEINS

Examiners

Primary: Kepplinger, Esther M.
Assistant: Saunders, David

Attorney, Agent or Firm

Pennie & Edmonds

International Classes

G01N 033/566
G01N 033/569
G01N 033/574
G01N 033/577

Abstract

The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis and therapy of diseases and disorders. The measurement of such molecules can be valuable in monitoring the effect of a therapeutic treatment on a subject, detecting and/or staging a disease in a subject, and in differential diagnosis of a physiological condition in a subject. These measurements can also aid in predicting therapeutic outcome and in evaluating and monitoring the immune status of patients.In specific embodiments, measurements of serum or plasma interleukin-2 receptor levels can be made, to detect or stage leukemia or lymphoma. In other embodiments, IL2R levels, or CD8 levels, can be used to differentially diagnose renal allograft rejection, as distinguished from Cyclosporin A nephrotoxicity. In another embodiment, CD8 levels can be measured to differentially diagnose rheumatoid arthritis, as distinct from other joint diseases.In particular embodiments, measurements of the soluble T cell surface molecules can be accomplished by sandwich enzyme immunuoassays.

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