U.S. patents available from 1976 to present.
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Improvements in redox systems for brain-targeted drug delivery

Patent 5002935 Issued on March 26, 1991. Estimated Expiration Date: Icon_subject March 26, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3459731

Stripe composition and method of reducing smell associated therewith
Patent #: 4024223
Issued on: 05/17/1977
Inventor: Noda ,   et al.

Inclusion complex of cyclodextrin and indomethacin and a process for the preparation thereof, method of use and pharmaceutical composition
Patent #: 4228160
Issued on: 10/14/1980
Inventor: Szejtli ,   et al.

ω-Halo-PGI2 analogues
Patent #: 4232009
Issued on: 11/04/1980
Inventor: Hayashi ,   et al.

3-Hydroxy and 3-oxo-prostaglandin analogues
Patent #: 4351846
Issued on: 09/28/1982
Inventor: Matsumoto ,   et al.

Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
Patent #: 4352793
Issued on: 10/05/1982
Inventor: Yamahira ,   et al.

Water-soluble steroid compounds
Patent #: 4383992
Issued on: 05/17/1983
Inventor: Lipari

Inclusion compound of p-hexadecylamino benzoic acid in cyclodextrin and method of use
Patent #: 4407795
Issued on: 10/04/1983
Inventor: Nicolau ,   et al.

3,4-Di -isobutyryloxy-N-[3-(4-isobutyryloxyphenyl)-1-methyl-n-propyl]-beta-phene thylamine cyclodextrin complexes
Patent #: 4424209
Issued on: 01/03/1984
Inventor: Tuttle

3,4-Dih ydroxy-N-[3-(4-dihydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamine cyclodextrin complexes
Patent #: 4425336
Issued on: 01/10/1984
Inventor: Tuttle

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Inventor

Assignee

Application

No. 139755 filed on 12/30/1987

US Classes:

514/58, Dextrin or derivative424/488, Polysaccharides (e.g., cellulose, etc.)514/778, Starch or derivative514/965, Discrete particles in supporting matrix536/103Dextrin or derivative

Examiners

Primary: Griffin, Ronald W.

Attorney, Agent or Firm

Foreign Patent References

  • 83/03968 WO. 11/13/1983
  • 85/02767 WO. 07/13/1985
  • 85/03937 WO. 09/13/1985

International Classes

A61K 031/44
A61K 031/445
A61K 009/22
C07D 213/82

Abstract

Inclusion complexes of hydroxypropyl-ଲ-cyclodextrin with the reduced biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine⇆pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The reodox inclusion complexes also provide a means for decreasing initial drug concentrations in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.

Other References

  • Pitha et al., in Controlled Drug Delivery, ed. S. D. Bruck, vol. I, CRC Press, Boca Raton, Fla., 125-148 (1983)
  • Uekama, Pharm. Int., Mar. 1985, 61-65
  • Pitha, Journal of Inclusion Phenomena 2, 477-485 (1984)
  • Pitha et al., International Journal of Pharmaceutics, 29, 73-82 (1986)
  • Uekama et al., in CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 3(1), 1-40 (1987)
  • Uekama, in Topics in Pharmaceutical Sciences 1987, eds. D. D. Breimer & P. Speiser, Elsevier Science Publishers B.V. (Biomedical Division), 181-194 (1987)
  • Pagington, Chemistry in Britain, 455-458 (May 1987)
  • Carpenter et al., Journal of Pediatrics, 111, 507-512 (Oct. 1987)
  • Estes et al., in Biological Approaches to the Controlled Delivery of Drugs, ed. R. L. Juliano, Annals of the New York Academy of Sciences, vol. 507, 1987, 334-33
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