U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Apparatus and method for in vivo analysis of red and white blood cell indices

Patent 4998533 Issued on March 12, 1991. Estimated Expiration Date: Icon_subject March 9, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method and apparatus for in-vivo spectroscopic analysis
Patent #: 4194217
Issued on: 03/18/1980
Inventor: van den Bosch

Eye fundus oximeter
Patent #: 4305398
Issued on: 12/15/1981
Inventor: Sawa

Angioscope Patent #: 4331132
Issued on: 05/25/1982
Inventor: Mukasa

Inventor

Application

No. 320896 filed on 03/09/1989

US Classes:

600/368, Physical characteristics of blood600/479, Cardiovascular testing600/558Eye or testing by visual stimulus

Examiners

Primary: Kamm, William E.
Assistant: Hanley, John C.

Attorney, Agent or Firm

International Classes

A61B 001/04
A61B 003/12
A61B 005/02

Abstract

Apparatus and methods for in vivo determination of red and white blood cell characteristics from a flow of red and white blood cells in mucous membranes are provided wherein image capturing means are employed to optically isolate images from a flow of blood cells and transmit those images to an image receiving means for encoding into electronic signals. The images are also filtered through light filters and subsequently transmitted to a computer for evaluation and analysis. The results of this analysis are then made available for display either on a CRT or hard copy printer.

Other References

  • Devaney et al, ISA Trans, vol. 15, No. 1, 1976, pp. 73-78
  • Fesler, Computers in Cardiology, Sep. 1979, pp. 379-382
  • Brown, IEEE Trans. Biomed. Engr., vol. BME-27, No. 3, Mar. 1980, pp. 132-138
  • Miller, IEEE Trans. Biomed Engr., vol. BME-23, No. 5, pp. 400-405, Sep. 1976
  • Megla, SID Journal, vol. 11, No. 5, Sep.-Oct. 1974, pp. 20-22
  • Johnson, Red Cell Separation in the Mesenteric Capillary Network, vol. 221, No. 1, American Journal of Physiology, Jul. 1971
  • Fagrell, Fronek, and Intaglietta, A Microscope-Television System For Studying Flow Velocity In Human Skin Capillaries, American Journal of Physiology, vol. 233, No. 2, (1977)
  • Fagrel, Intaglietta and Ostergren, Relative Hematocrit in Human Skin Capillaries and Its Relation to Capillary Blood Flow Velocity, Microvascular Research, vol. 20, pp. 327-335 (1980)
  • Safranyos, Ellis, Tyml, and Groom, Heterogeneity of Capillary Diameters in Skeletal Muscle of the Frog, Microvascular Research, vol. 26, pp. 151-156 (1983)
  • Mickols, Maestre, Tinoco, Jr., and Embury, Visualization of Oriented Hemoglobin S in Individual Erythrocytes by Differential Extinction of Polarized Light, Proceedings of the National Academy of Sciences, U.S.A., vol. 82, pp. 6527-6531, Oct. 1985
  • Ellis, Safranyos, and Groom, Television-Computer Method for in Vivo Measurement of Capillary Diameter, Based on the Passage of Red Cells, Microvascular Research, vol. 26, pp. 139-150 (1983
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