Soft steroids having anti-inflammatory activity
Patent 4996335 Issued on February 26, 1991. Estimated Expiration Date: 
February 26, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 26, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3558675 3856828 Pharmaceutical compositions of 6,9-difluoro-androst-4-ene-17ଲ-carboxylates and derivatives thereof Corticoid 17-(alkyl carbonates) and processes for their preparation Thio etianic acid derivatives Corticoid-17-(alkyl carbonates) and process for their manufacture Patent #: 4377575 InventorAssigneeApplicationNo. 807034 filed on 12/09/1985US Classes:552/610, Acyclic carbon bonded directly at the 17 beta-position of the cyclopentanohydrophenanthrene ring system (e.g., etiocholanic acids, 17 cyanoetiocholanes, 17-aldehydrostanes, etc.)552/611, Exactly one oxygen bonded directly to the cyclopentanohydrophenanthrene ring system (e.g., 3-keto-etiocholanic acids, etc.)552/612Three or more oxygens bonded directly to the cyclopentanohydrophenanthrene ring systemExaminersPrimary: Friedman, Stanley J.Assistant: Criares, Theodore J. Attorney, Agent or FirmInternational ClassesC07J 003/00A01N 043/50 AbstractThe invention provides novel soft steroidal anti-inflammatory agents, pharmaceutical compositions containing said agents, and methods of administering same to mammals in the treatment of inflammation. Preferred compounds of the invention include haloalkyl 17-alkoxycarbonyloxy-11ଲ-hydroxyandrost-4-en-3-one-17ଲ-ca rboxylates and the corresponding Ɗ1,4 compounds, optionally bearing 6- and/or 9-fluorine and 16- or 16ଲ-methyl substituents. Especially preferred compounds include haloalkyl 17-alkoxycarbonyloxy-9-fluoro-11ଲ-hydroxy-16-methylandr osta-1,4-dien-3-one-17ଲ-carboxylates. |
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