Combined topical and systemic method of administration of cyclosporine
Patent 4996193 Issued on February 26, 1991. Estimated Expiration Date: March 3, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
The present invention provides formulations for the topical application of cyclosporin to skin tissue for treatment of autoimmune, T-cell mediated immune disease, and inflammatory conditions, and for producing prolonged skin allograft survival and wound healing. In addition, methods for the use of said formulations--in tandem with systemic applications of cyclosporin or without same--are suggested. The present invention also suggests alternative formulations and delivery systems for the efficacious treatment of the aforementioned conditions, and further suggests a model with which formulations may be tested.
Other References
C. W. Hewitt et al., "Cyclosporine and Skin Allografts for the Treatment of Thermal Injury: I. Extensive Graft Survival with Low-Level Long-Term Administration and Prolongation in a Rat Burn Model", Transplantation 45: 13 (1988)
A. D. Hess et al., "Mechanisms of Action of Cyclosporine: Effect on Cells of the Immune System and on Subcellular Events in T Cell Activation", Transpl. Proc. 20: 29 (1988)
C. N. Ellis et al., "Cyclosporine Improves Psoriasis in a Double-Blind Study", JAMA 256: 3110 (1986)
L. H. Toledo-Pereyra et al., "Prolongation of Kidney Transplant Survival by Cyclosporine A Graft Pretreatment", Transplantation 33: 330 (1982)
R. D. Aldridge et al., "Inhibition of Contact Sensitivity Reactions to DNFB by Topical Cyclosporin Application in the Guinea-Pig", Clin. Exp. Immunol. 59: 23 (1985)
C. S. Lai et al., "Long-Term Survival of Skin Allografts in Rats Treated with Topical Cyclosporine", 44: 83 (1987)
X. F. Zhao et al., "The Prolongation of Skin Allograft Survival by Topical Use of Cyclosporine A", Transpl. Proc. 20: 670 (1988)
E. Towpik et al., "Cyclosporine and Experimental Skin Allografts", Transpl. 40: 714 (1985)
Biren et al., "Prolonged Viability of Human Skin Xenografts in Rats by Cyclosporine", J. Invest. Dermatol. 86: 611 (1986)
M. Ried et al., "Cyclosporine Levels in Human Tissues of Patients Treated for One Week to One Year", Transpl. Proc. 15: 2434 (1983)
J. Thivolet et al., "Effects of Cyclosporin on Bullous Pemphigoid and Pemphigus", Lancet 1: 334 (1985)
J. I. Harper et al., "Cyclosporine for Psoriasis", Lancet 2: 981 (1984)
A. W. Thompson et al., "Topical Cyclosporin and Immunologically Mediated Skin Disorders", Lancet 1: 1212 (1987)
M. W. Mosteller et al., "Penetration of Topical Cyclosporine into the Rabbit Cornea, Aqueous Humor, and Serum", Arch Opthalmol 103: 101 (1985)
S. Levinger et al., "Effects of Systemic Administration of Chlorambucil and Topical Application of Cyclosporin A on Corneal Graft Survival in Rabbits", Isr. J. Med. Sci. 21: 670 (1985)
G. F. Babcock et al., "Prolongation of Skin and Graft Survival with Topical Immunosuppression", Seventh International Congress on Burn Injuries, Melbourne, Australia (Feb. 1986)
S. Shuster, "Cyclosporine in Dermatology", Transpl. Proc. 20: 19 (1988)
K. S. Black et al, "Transdermal Application of Cyclosporine Prolongs Skin Allograft Survival", Transpl. Proc. 20: 660 (1988)
C. A. Biren et al., "Dermatologic Applications of Cyclosporine", Arch Dermatol. 122: 1028 (1986)
R. D. Aldridge et al., "Cyclosporine and Skin Disease", Lancet 1: 160 (1985)
W. Muller et al., "Cyclosporin A for Psoriasis", NEJM 301: 555 (1979
March 3, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
