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AbstractThe present invention provides formulations for the topical application of cyclosporin to skin tissue for treatment of autoimmune, T-cell mediated immune disease, and inflammatory conditions, and for producing prolonged skin allograft survival and wound healing. In addition, methods for the use of said formulations--in tandem with systemic applications of cyclosporin or without same--are suggested. The present invention also suggests alternative formulations and delivery systems for the efficacious treatment of the aforementioned conditions, and further suggests a model with which formulations may be tested.Other References
| InventorsAssigneeApplicationNo. 318676 filed on 03/03/1989US Classes:514/11, Monocyclic514/885, IMMUNE RESPONSE AFFECTING DRUG514/886, INFLAMMATION, SKIN514/887Topical TreatmentField of Search514/11, Monocyclic514/825, ARTHRITIS514/885, IMMUNE RESPONSE AFFECTING DRUG514/886, INFLAMMATION, SKIN514/887Topical TreatmentExaminersPrimary: Cashion, Merrell C. Jr.Assistant: Kishore, G. S. Attorney, Agent or FirmUS Patent References3288824, 4108985, Dihydrocyclosporin CIssued on: 08/22/1978 Inventor: Ruegger , et al.4117118, Organic compounds Issued on: 09/26/1978 Inventor: Harri , et al.4210581, Organic compounds Issued on: 07/01/1980 Inventor: Ruegger , et al.4220641, Organic compounds Issued on: 09/02/1980 Inventor: Traber , et al.4288431, Cyclosporin derivatives, their production and pharmaceutical compositions containing them Issued on: 09/08/1981 Inventor: Traber , et al.4289851, Process for producing cyclosporin derivatives Issued on: 09/15/1981 Inventor: Traber , et al.4384996, Novel cyclosporins Issued on: 05/24/1983 Inventor: Bollinger , et al.4388307, Galenical compositions Issued on: 06/14/1983 Inventor: Cavanak4396542, Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production Issued on: 08/02/1983 Inventor: Wenger4553974, Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor Issued on: 11/19/1985 Inventor: Dewanjee4554351, Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production Issued on: 11/19/1985 Inventor: Wenger4639434, Novel cyclosporins Issued on: 01/27/1987 Inventor: Wenger , et al.4649047, Ophthalmic treatment by topical administration of cyclosporin Issued on: 03/10/1987 Inventor: Kaswan4677968, Methods of testing the reaction of various substances on living human skin Issued on: 07/07/1987 Inventor: Krueger4681754, Counteracting cyclosporin organ toxicity Issued on: 07/21/1987 Inventor: Siegl4703033, Novel cyclosporins Issued on: 10/27/1987 Inventor: Seebach4764503, Novel cyclosporins Issued on: 08/16/1988 Inventor: Wenger4771122, Novel cyclosporins Issued on: 09/13/1988 Inventor: Seebach4839342, Method of increasing tear production by topical administration of cyclosporin Issued on: 06/13/1989 Inventor: Kaswan4857662N-phenylbenzamide derivatives Issued on: 08/15/1989 Inventor: Satzinger , et al. Foreign Patent References
International ClassA61K 037/02 |