U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Antiinflammatory compositions and methods

Patent 4994457 Issued on February 19, 1991. Estimated Expiration Date: Icon_subject February 19, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Benzothiazine derivative
Patent #: 4376768
Issued on: 03/15/1983
Inventor: Ozaki ,   et al.

Water-soluble benzothiazine dioxide salts
Patent #: 4434163
Issued on: 02/28/1984
Inventor: Lombardino

Crystalline benzothiazine dioxide salts
Patent #: 4434164
Issued on: 02/28/1984
Inventor: Lombardino

Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
Patent #: 4551452
Issued on: 11/05/1985
Inventor: Marfat

Antiinflammatory compositions and methods
Patent #: 4559326
Issued on: 12/17/1985
Inventor: Crawford ,   et al.

Antiinflammatory methods Patent #: 4564614
Issued on: 01/14/1986
Inventor: Crawford ,   et al.

Inventors

Application

No. 066352 filed on 05/19/1987

US Classes:

514/226.5, One of the cyclos is a 1,2-thiazine (e.g.,1,2-benzothiazines, etc.)514/922, SIDE EFFECT REDUCTION BY INCORPORATION OF A SECOND DESIGNATED INGREDIENT514/925, ULCER TREATMENT514/927Peptic

Examiners

Primary: Goldberg, Jerome D.
Assistant: Craires, Theodore J.

Attorney, Agent or Firm

Foreign Patent References

  • 2426106 DE 01/13/1975
  • 2078738 GB. 01/13/1982
  • 8400490 WO. 02/13/1984

International Classes

A61K 031/54
A61K 049/00

Abstract

An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as piroxicam, or a pharmaceutically acceptable salt thereof, with 5'-guanylic acid or N-acetyl-L-methionine, or a pharmaceutically acceptable salt thereof.

Other References

  • Dobrescu et al., Chem. Abstr. 79(3):16639g (1973)
  • The Merck Index, 10th Ed., 1983, p. 658, No. 4452
  • Chemical Abstracts 83, 188283K, 1975; abstracting Ishii et al., Nippon Yakurigaku Zasshi, 70(6), 863-9 (1974)
  • Chemical Abstracts 81, 99415w, 1974; abstracting Fukawa et al., Oyo Yakuri 7(9-10); 1339-48 (1973)
  • Chemical Abstracts 66, 112545a, 1967; abstracting Bole et al., J. Lab. Clin. Med. 69(4), 610-23 (1967)
  • Urushidani et al., Japan J. Pharmacol., vol. 27, pp. 316-319 (1977)
  • Tanaka et al., Japan J. Pharmacol., vol. 32, pp. 307-313 (1982)
  • Kunimi et al., Japan J. Pharmacol., vol. 32, pp. 469-477 (1982)
  • Lim et al., J. Pharm. Sci., vol. 68, pp. 295-298 (1979
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