Method and structures employing chemically-labelled polynucleotide probes
Patent 4994373 Issued on February 19, 1991. Estimated Expiration Date: 
July 20, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 20, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3652761 Specific DNA probes in diagnostic microbiology Test strip kits in immunoassays and compositions therein Immobilization of message RNA directly from cells onto filter material Method of detecting and characterizing a nucleic acid or reactant for the application of this method Patent #: 4581333 InventorsAssigneeApplicationNo. 385986 filed on 07/20/1989US Classes:435/6, Involving nucleic acid435/4, MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/810, PACKAGED DEVICE OR KIT436/94, Saccharide (e.g., DNA, etc.)436/501, BIOSPECIFIC LIGAND BINDING ASSAY436/521, Fixation or stabilization of red blood cells436/527, Glass or silica436/531, Carrier is synthetic resin436/532, Antigen or antibody attached to a carrier via bridging agent436/800, FLUORESCENT DYES (E.G., RHODAMINE, ETC.)436/810, Tube, bottle, or dipstick536/24.3Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNAExaminersPrimary: Wax, Robert A.Assistant: Marschel, Ardin H. Attorney, Agent or FirmInternational ClassesC12Q 001/68C07H 021/00 G01N 033/533 AbstractPolynucleotide sequences in a sample of biological or nonbiological material are detected by a method involving fixing of the sequences on a solid support and forming an entity between the fixed sequences and chemically-labeled polynucleotide or oligonucleotide probes having a sequence complementary to the fixed sequence for determining the identification and/or presence of the target polynucleotide sequences. The chemical label covalently or noncovalently attached to the probe comprises a signalling moiety capable of generating a soluble signal detectable by spectrophotometric assay techniques. |
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