N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans and derivatives

Patent 4990617 Issued on February 5, 1991. Estimated Expiration Date:

July 27, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

2813097

2813098

3131185

3144459

3217006

3299072

N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes Patent #: 4722928
Issued on: 02/02/1988
Inventor: Boswell , et al.

Inventors

Assignee

E. I. Du Pont de Nemours and Company

Application

No. 391406 filed on 07/27/1989

US Classes:

546/44, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)540/477, Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc.)546/46A single chalcogen is bonded directly to ring carbon of the pentacyclo ring system (e.g., desoxy morphine, etc.)

Examiners

Primary: Rotman, Alan L.

International Classes

C07D 221/26
C07D 221/28
C07D 487/08

Abstract

N-oxide prodrug derivatives of 3-hydroxy morphinan and partial morphinan analgesics, agonist-antogonists, and narcotic antagonists are useful therapeutic entities which provide enhanced bioavailability of 3-hydroxy morphinans and partial morphinans from orally administered dosage forms.

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