Controlled release hydromorphone composition
Patent 4990341 Issued on February 5, 1991. Estimated Expiration Date: 
April 28, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 28, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDispenser with diffuser Osmotic system with instant drug availability Pharmaceutical products providing enhanced analgesia Testicular-specific drug delivery Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration Patent #: 4806341 InventorsAssigneeApplicationNo. 345354 filed on 04/28/1989US Classes:424/484, Matrices424/495, Ethyl cellulose424/496, Containing natural gums/resins424/497, Containing solid synthetic polymers424/498, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof424/499, Contains proteins or derivative or polysaccharides or derivative424/501, Contains solid synthetic resin424/502Contains waxes, higher fatty acids, higher fatty alcoholsExaminersPrimary: Page, Thurman K.Attorney, Agent or FirmInternational ClassA61K 009/20Foreign Application Priority Data1987-10-26 GBAbstractA solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of hydromorphone or a salt thereof in a matrix wherein the dissolution rate in vitro of the dosage form, when measured by the USP Paddle Method of 100 rpm in 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37° C. is between 12.5% and 42.5% (by weight) hydromorphone released after 1 hour, between 25% and 55% (by weight) hydromorphone released after 2 hours, between 45% and 75% (by weight) hydromorphone released after 4 hours and between 55% and 85% (by weight) hydromorphone released after 6 hours, the in vitro release rate being independent of pH between pH 1.6 and 7.2 and chosen such that the peak plasma level of hydromorphone obtained in vivo occurs between 2 and 4 hours after administration of the dosage form.Other References
Field of SearchWith porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)Ethyl cellulose Cellulose or derivative Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof Matrices Polysaccharides (e.g., cellulose, etc.) Containing polysaccharides (e.g., sugars) Containing natural gums/resins Containing solid synthetic polymers Contains proteins or derivative or polysaccharides or derivative Contains solid synthetic resin Contains waxes, higher fatty acids, higher fatty alcohols | |
