Method of making lipid tubules by a cooling process
Patent 4990291 Issued on February 5, 1991. Estimated Expiration Date: 
February 29, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 29, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for the preparation of liposomes Process for hardening microcapsules Process for making lipid membrane structures Liposomes and their use in treating human or other mammalian patients Synthetic phosphatidyl cholines useful in forming liposomes Patent #: 4485045 InventorsApplicationNo. 161934 filed on 02/29/1988US Classes:264/4.7, Solid-walled microcapsule formed by in situ polymerization264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)424/450, Liposomes514/832, BLOOD SUBSTITUTE514/885, IMMUNE RESPONSE AFFECTING DRUG522/171Processes of preparing a solid polymer from at least one phosphorous containing monomer; or compositions thereforeExaminersPrimary: Lovering, Richard D.Attorney, Agent or FirmInternational ClassesA61K 009/127B01J 013/18 AbstractDiacetylinic phosophocholines have distinctly different endothermic and exothermic transition temperatures. Lipid tubules are formed by hydrating a diacetylinic phosphocholine at a temperature above its endothermic transition temperature. The hydrated lipid is then cooled slowly to a formation temperature 1° to 10° C. below the exothermic transition temperature to form tubule structures. The tubules structures can be polymerized to form permanent tubules. The tubules can be used in the same manner as a liposome vesicle or they can be metal coated for a variety of applications.Other References
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