Percutaneous-administration-type pharmaceutical preparation of nitroglycerin
March 31, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesTherapeutic system for administering drugs to the skin Polymeric diffusion matrix containing a vasodilator Transdermal nitroglycerin pad Pressure-sensitive adhesive tape or pressure-sensitive adhesive sheet containing nitroglycerin Polymeric diffusion matrix Polymeric diffusion matrix Medicinal adhesive sheets for heart diseases and a process for the preparation thereof Hydrophilic therapeutic material Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes Transdermal nitroglycerin delivery system Inventors
AssigneeApplicationNo. 175820 filed on 03/31/1988US Classes:424/448, Pressure sensitive adhesive means424/443Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicamentsExaminersPrimary: Page, Thurman K.Attorney, Agent or FirmForeign Patent References
International ClassA61F 013/02Foreign Application Priority Data1987-03-31 JPAbstractA percutaneous-administration-type pharmaceutical preparation of nitroglycerin comprising a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is disposed on one surface of the backing, wherein the pressure-sensitive adhesive layer contains alkyl (meth)acrylate copolymer in the concentration of 80-95% by weight and the nitroglycerin in the concentration of 5-20% by weight, said copolymer contains as major copolymer components alkyl (meth)acrylate with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexylmethacrylate in the concentration of 40-90% by weight based on the total weight of said alkyl (meth)acrylates, and the copolymer has a rolling ball tack value of 2 or less. The preparation obtained makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for long periods of time.Other References
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