Compositions and methods for administering therapeutically active compounds
Patent 4968716 Issued on November 6, 1990. Estimated Expiration Date: 
September 19, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 19, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3459863 3781423 InventorAssigneeApplicationNo. 246504 filed on 09/19/1988US Classes:514/474, Ascorbic acid or derivative (e.g., vitamin C, etc.)514/165, Aspirin per se (i.e., 2-(acetyloxy)benozic acid)514/198, Ampicillin per se or salt thereof514/413, Ring nitrogen is shared by the cyclos of the bicyclo ring system514/419, C=X bonded directly or indirectly by an acyclic carbon or carbon chain to ring carbon of the five-membered hetero ring (e.g., tryptophan, etc.) (X is chalcogen)514/563, RC(=O)N containing (i.e., carboxamide) (R is C or H)514/564, Plural nitrogens nonionically bonded514/567, Benzene ring nonionically bonded514/569, Polycyclo ring system514/570, Carboxy or salt thereof only attached indirectly to the benzene ring514/629, R is hydrogen or a lower saturated alkyl of less than seven carbons514/946PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED)ExaminersPrimary: Robinson, Douglas W.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/34A61K 031/60 A61K 031/19 A61K 031/195 AbstractA composition useful for administering therapeutically active compounds to improve the body absorption and/or retention thereof comprising a composition which includes a therapeutically active compound having a molecular weight below about 5,000 and having an acidic functional group, which is normally eliminated from the body via the renal tubular secretion pathway for organic anions, for example, Vitamin C, and at least one compound selected from the class consisting of L-threonic, L-xylonic and L-lyxonic acids, and the edible salts, aldono-lactones and aldono-lactides thereof.A method for establishing and maintaining body levels of a therapeutically active compound which includes the step of administering a therapeutically effective dose of this composition.Other References
Field of SearchAspirin per se (i.e., 2-(acetyloxy)benozic acid)Ascorbic acid or derivative (e.g., vitamin C, etc.) Chalcogen bonded directly to ring carbon of the hetero ring Chalcogen bonded directly to the hetero ring Ampicillin per se or salt thereof Ring nitrogen is shared by the cyclos of the bicyclo ring system C=X bonded directly or indirectly by an acyclic carbon or carbon chain to ring carbon of the five-membered hetero ring (e.g., tryptophan, etc.) (X is chalcogen) RC(=O)N containing (i.e., carboxamide) (R is C or H) Plural nitrogens nonionically bonded Benzene ring nonionically bonded Polycyclo ring system Carboxy or salt thereof only attached indirectly to the benzene ring R is hydrogen or a lower saturated alkyl of less than seven carbons PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED) | |
