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Osteogenic proteins and polypeptides

Patent 4968590 Issued on November 6, 1990. Estimated Expiration Date: Icon_subject April 8, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Bone morphogenetic protein process
Patent #: 4294753
Issued on: 10/13/1981
Inventor: Urist

Bone graft material for osseous defects and method of making same
Patent #: 4394370
Issued on: 07/19/1983
Inventor: Jefferies

Partially purified osteogenic factor and process for preparing same from demineralized bone
Patent #: 4434094
Issued on: 02/28/1984
Inventor: Seyedin ,   et al.

Bone morphogenetic protein
Patent #: 4455256
Issued on: 06/19/1984
Inventor: Urist

Inductive collagen based bone repair preparations
Patent #: 4563350
Issued on: 01/07/1986
Inventor: Nathan ,   et al.

Biodegradable organic polymer delivery system for bone morphogenetic protein
Patent #: 4563489
Issued on: 01/07/1986
Inventor: Urist

Osteoinductive factors Patent #: 4877864
Issued on: 10/31/1989
Inventor: Wang, et al.

Inventors

Assignee

Application

No. 179406 filed on 04/08/1988

US Classes:

530/326, 15 to 23 amino acid residues in defined sequence530/327, 11 to 14 amino acid residues in defined sequence530/328, 8 to 10 amino acid residues in defined sequence530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/840Bones; tendons; teeth; cartilage

Examiners

Primary: Nutter, Nathan M.

Attorney, Agent or Firm

Foreign Patent References

  • 0128041 EP. 12/13/1984
  • 0148155 EP. 07/13/1985
  • 0169016 EP. 01/13/1986
  • 0182483 EP. 05/13/1986
  • 0212474 EP. 03/13/1987
  • 8505274 WO. 12/13/1985
  • 8600526 WO. 01/13/1986
  • 8800205 WO. 01/13/1988
  • US8904458 WO. 10/13/1989
  • 8909605 WO. 10/13/1989
  • 8910409 WO. 11/13/1989

International Classes

A61K 037/02
C07K 005/00
C07K 007/00
C07K 015/00

Abstract

Disclosed are osteogenic devices comprising a matrix containing substantially pure mammalian osteogenic protein and methods of inducing endochondral bone growth in mammals. A partial amino acid sequence, amino acid composition, solubility properties, and various other data characterizing osteogenic protein are also disclosed, as well as a nucleic acid sequences encoding a consensus osteogenic protein.

Other References

  • Wang et al., PNAS, vol. 87, pp. 2220-2224, Mar. 1990
  • Colowick et al., Methods in Enzymology 146:294-312 (1987)
  • Olson et al., Analyt. Biochem. 146:232-237 (1985)
  • Seyedin et al., J. Cell Biol. 97:1950-1953 (1983)
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  • Urist et al. (1984) Clin. Orth. Rel. Res. 187:277-280
  • Urist, Huo et al. (1984) Proc. Natl. Acad. Sci. U.S.A. 81:371-375
  • Reddi (1985) Journal of Biomedical Materials Research 19:233-239
  • Seyedin et al. (1985) Proc. Natl. Acad. Sci. U.S.A. 82:2267-2271
  • Klausner (1985) Biotechnology 3:567-568
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  • Weeks et al. (1987) Cell 51:861-867
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  • LeGendre and Matsudaira (1988) Biotechniques 6:154-15
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