U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Topical ophthalmic compositions containing microfine retinoid particles

Patent 4966773 Issued on October 30, 1990. Estimated Expiration Date: Icon_subject April 17, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3506760

3828777

3843782

3920810

Polystyrene sulfonate containing opthalmic solutions
Patent #: 3987163
Issued on: 10/19/1976
Inventor: Rankin

Ophthalmic solution
Patent #: 4039662
Issued on: 08/02/1977
Inventor: Hecht ,   et al.

Treatment of dry eye
Patent #: 4131651
Issued on: 12/26/1978
Inventor: Shah ,   et al.

Treatment of infectious keratoconjunctivitis in animals
Patent #: 4219545
Issued on: 08/26/1980
Inventor: Collins

Tretinoin in a gel vehicle for acne treatment
Patent #: 4247547
Issued on: 01/27/1981
Inventor: Marks

Artificial tear aid Patent #: 4421748
Issued on: 12/20/1983
Inventor: Trager ,   et al.

Inventors

Application

No. 339915 filed on 04/17/1989

US Classes:

424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/78.04, Ophthalmic preparation514/559, Ring containing514/693, Aldehyde DOAI514/724, C-O-group (e.g., alcohol, alcoholate, etc.) DOAI514/912, OPHTHALMIC514/915Wetting agent

Examiners

Primary: Robinson, Douglas W.
Assistant: Fay, Zohreh

Attorney, Agent or Firm

Foreign Patent References

  • 844544 BE. 01/13/1977
  • 0077197 EP. 04/13/1983
  • 1431841 GB. 09/13/1973
  • 1430223 GB. 03/13/1976

International Classes

A61K 009/14
A61K 031/13
A61K 031/20
A61K 031/045

Abstract

Topical ophthalmic compositions containing microfine particles of one or more retinoids are described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.

Other References

  • Chem. Abst. 86: 111126(r) (1977)-List et al
  • Arvo-1984-Ubel et al.,-3-9:00-"Vitamin A is Present as Retinol in Tears", Dispersa-Theapeutic Index-Feb. 1981
  • Tseng, "Topical Vitamin A Treatment for Dry Eye Disorders", Science Writers Seminar in Ophthalmology, 9-30-10-3, Research to Prevent Blindness, pp. 1-6 (1984)
  • Sommer et al., "Topical Retinoic Acid in the Treatment of Corneal Xerophthalmia", Am. Journal of Ophthalmology, vol. 86, pp. 615-617 (1978)
  • Van Horn et al., "Topical Retinoic Acid in the Treatment of Experimental Xerophthalmia in the Rabbit", Archives of Ophthalmology, vol. 99, pp. 317-321, 1981
  • Pirie, "Effects of Locally Applied Retinoic Acid on Corneal Xerophthalmia in the Rat", Experimental Eye Research, vol. 25, pp. 297-302 (1977)
  • Ubels et al., "Healing of Experimental Corneal Wounds Treated with Topically Applied Retinoids", Am. Journal of Ophthalmology, vol. 95, pp. 353-358 (1983)
  • Smolin et al., "Tretinoin and Corneal Epithelial Wound Healing", Archives of Ophthalmology, vol. 97, pp. 545-546 (1979)
  • Hatchell et al., "Treatment of Xerophthalmia with Retinol, Tretinoin and Etretinate", Archives of Ophthalmology, vol. 102, pp. 926-927 (1984)
  • Grosz, "Local Use of Vitamin A Preparation in Ophthalmic Practice", Archives of Ophthalmology, vol. 5, pp. 727-734 (1939)
  • Sommer, "Treatment of Corneal Xerophthalmia with Topical Retinoic Acid", Am. Journal of Ophthalmology, vol. 95, pp. 349-352 (1983)
  • Hatchell et al., "Corneal Epithelial Wound Healing in Normal and Diabetic Rabbits Treated with Tretinoin", Archives of Ophthalmology, vol. 103, pp. 98-100 (1985)
  • Tseng et al., "Topical Retinoid Treatment for Various Dry-Eye Disorders", Ophthalmology, vol. 92, pp. 718-727 (1985
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