Human stem cells and monoclonal antibodies

Patent 4965204 Issued on October 23, 1990. Estimated Expiration Date:

October 23, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing same
Patent #: 4364932
Issued on: 12/21/1982
Inventor: Kung , et al.

Monoclonal antibody to a human T cell antigen and methods of preparing same
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Issued on: 12/21/1982
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Anti-human T-lymphocyte monoclonal antibody
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Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins
Patent #: 4582797
Issued on: 04/15/1986
Inventor: Trowbridge

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Issued on: 11/25/1986
Inventor: Kung , et al.

Monoclonal antibody for human hematopoietic glycoproteins and method
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Human stem cells Patent #: 4714680
Issued on: 12/22/1987
Inventor: Civin

Inventor

Civin, Curt I.

Assignee

The Johns Hopkins University

Application

No. 055942 filed on 06/01/1987

US Classes:

530/388.7, Binds hematopoietic cell or component or product thereof (e.g., erythrocyte granulocyte, macrophage, monocyte, platelet, myelogenous leukemia cell, bone marrow stem cell, granulocytic cell-surface antigen, hemoglobin, thrombospondin, glycophorin, etc.)424/93.7, Animal or plant cell424/140.1, Extracorporeal or ex vivo removal of antibodies or immune complexes (e.g., removal of autoantibodies, etc.); or extracorporeal or ex vivo removal of antigen by antibodies (e.g., removal of cancer cells from bone marrow by antibodies, etc.)435/7.21, Animal cell435/343, Binds a hematopoietic cell or component or product thereof (e.g., erythrocyte, granulocyte, macrophage, monocyte, platelet, myelogenous leukemia cell, bone marrow stem cell, granulocytic cell surface antigen, hemoglobin, thrombospondin, glycophorin, etc.)530/388.73, Binds lymphocytic or lymphocytic-like cell or component or product thereof (e.g., B cell, B-lineage bone marrow cell, null cell, natural killer cell, B-lymphoblastoid cell, B-lineage acute lymphoblastic leukemia cell, B-lymphocytic cell-surface antigen, etc.)530/809Fused cells, e.g., hybridoma, etc.

Examiners

Primary: Moskowitz, Margaret
Assistant: Cunningham, Thomas M.

Attorney, Agent or Firm

Banner, Birch, McKie & Beckett

International Classes

C12N 005/00
C07K 015/00
A61K 039/00

Abstract

Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as therapeutic methods employing the cell suspensions.

Other References

Perschel et al., "M7 Cluster Report: CD34," ed. Knapp, et al., at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 817
Civin et al., "M7.1 Report on the CD34 Cluster Workshop," ed. Knapp, et al., at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 818
Lansdorp et al., "M7.2 CD34 Epitopes," ed. Knapp, et al., at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 826
Molgaard et al., "M7.3 Molecular Characterization of Human and Murine CD34," ed. Knapp, et al. at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 827
Civin, C. I., "Antigenic Analysis of Hematopoieses III. a Hematopoietic Progenitor Cell Surface Antigen Defined by a Monoclonal Antibody Raised Against KG-Ia Cells" (1984), J. Immunology 133:157-165
Civin Strauss et al., (1982) Blood 60(5):95a (abstract)
Civin, Vaughan et al., "Cell Surface Antigens of Human Myeloid Cells", (1982) Exp. Hematol. 10:129 (abstract)
Civin, Brovall et al. (1983) Hybridoma 2:125a, presented Feb. 8, 1983, abstracts available Feb. 6, 1983
Brovall, Shaper, Civin et al. (1983) Exp. Hematol. II (Supp.):199, presented Jul. 14, 1983, abstract available Jul. 10, 1983
Civin, Vaughan, et al. (1983) Exp. Hematol. II (Supp.):84, presented Jul. 12, 1983, abstract available Jul. 10, 1983
Strauss and Civin (1983) Exp. Hematol. II:205, presented Jul. 14, 1983, abstracts available Jul. 10, 1983
Strauss and LaRusa and Civin (1984) I.S.E.H. Abstract
Leary, Ogawa, Civin et al. (1984) I.S.E.H. Abstract
Bodger, et al., "Surface Antigenic Determinants on Human Pluripotent and Unipotent Hematopoietic Progenitor Cells", Blood, vol. 61, pp. 1006-1010 (1983)
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