Metal complexes of N-methyl-11-aza-10-deoxo-10-dihydro-erythromycin A or 11-aza-10-deoxo-10-dihydro-erythromycin A, method for the manufacture thereof and their use in the manufacture of pharmaceuticals
Patent 4963528 Issued on October 16, 1990. Estimated Expiration Date: 
October 16, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 16, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References11-Aza-10-deoxo-10-dihydroerythromycin A and derivatives thereof as well as a process for their preparation N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor 3-O-Demethyl derivatives of the istamycin B series of compounds Patent #: 4499083 InventorsAssigneeApplicationNo. 094555 filed on 09/09/1987US Classes:514/29, The hetero ring has exactly 13 ring carbons (e.g., erythromycin, etc.)536/7.2, Erythromycin or derivative (e.g., oleandomycin, etc.)536/7.4Additional nitrogen containingExaminersPrimary: Brown, Johnnie R.Assistant: Peselev, Elli Attorney, Agent or FirmInternational ClassesA61K 031/71C07H 017/08 Foreign Application Priority Data1986-09-12 YUAbstractNew 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen form the group comprising Cu+2, Zn+2, Co+2, Ni+2 and Ca+2, a process for their manufacture and their use in the manufacture of antibiotically active pharmaceuticals.New 2:1 complexes of N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A with bivalent metals chosen from the group comprising Cu+2, Zn+2, Co+2, Ni+2 and Ca+2 are made by reacting N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A or 11-aza-10-deoxo-10-dihydroerythromycin A in its free base form or in its water-soluble salt form with salts of said bivalent metals. The compounds possess antibiotic activity.Other References
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