Patent 4961931 Issued on October 9, 1990. Estimated Expiration Date: September 9, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/430, Vaginal, urethral, uterine424/431, Tampon424/432, IUD or ring424/433, Depot, pellet, matrix, or suppository604/285, Treating material insert retained in body orifice604/288, Soluble in body (e.g., suppository, etc.)604/515To or from the female reproductory tract
The invention is for a vaginal dispenser comprising a wall surrounding an internal lumen and having a pair of ends with one end placed inside the other end to form a closed dispenser. A vaginally administrable beneficial agent is housed in the lumen for release by the dispenser over time.
Other References
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Gambrell, Jr., M.D., R. Don, "The Menopause: Benefits and Risk of Estrogen-Progestogen Replacement Therapy", Fertility and Sterility, vol. 37, No. 4, (Apr. 1982), pp. 457-473
Whitehead, M. I. & Campbell, S., "Endometrial Histology, Uterine Bleeding and Oestrogen Levels in Menopausal Women Receiving Oestrogen Therapy and Oestrogen Progestogen Therapy", pp. 65-80, Endometrial Cancer, edited by Brush, M. G., King, R. J. B. & Taylor, R. W., (1977), Bailliere Tindall-London
King, R. J. B., Whitehead, M. I., Campbell, S. & Minardi, Jane, "Effects of Estrogens and Progestogens on the Biochemistry of the Post-Menopausal Endometrium," pp. 111-119, The Role of Estrogen/Progestogen in the Management of the Menopause, Proceedings of a Symposium held at the U. of Sheffield on Mar. 16, 1987, MTP Press, Ltd., Lancaster, England
Gal, M.D., David, Edman, M.D., Clare D., et al., "Long-Term Effect of Megestrol Acetate in the Treatment of Endometrial Hyperplasia," pp. 316-322, Am. J. Obstet. Gynecol., vol. 146, No. 3, (Jun., 1983