Pyrrole derivatives, and pharmaceutical compositions which contain them and pharmacological methods of use
Patent 4960779 Issued on October 2, 1990. Estimated Expiration Date: 
June 1, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 1, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3884921 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives Condensed pyrrolinone derivatives, their production and use Patent #: 4590189 Inventors
AssigneeApplicationNo. 360122 filed on 06/01/1989US Classes:514/300, Plural hetero atoms in the bicyclo ring system514/312, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding514/313, Nitrogen, other than as nitro or nitroso, attached directly to the six membered hetero ring by nonionic bonding514/339, Ring nitrogen in the polycyclo ring system546/122, The other cyclo in the bicyclo ring system is also six-membered (e.g., naphthyridines, etc.)546/153, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding546/159, Nitrogen, other than as nitro or nitroso, attached directly to the six membered hetero ring by nonionic bonding546/162, Nitrogen attached indirectly to the six-membered hetero ring through the directly attached nitrogen by nonionic bonding546/276.7, Polycyclo ring system having the five-membered hetero ring as one of the cyclos546/277.1Bicyclo ring system which is isoindole (including hydrogenated)ExaminersPrimary: Rotman, Alan L.Assistant: McKane, J. K. Attorney, Agent or FirmForeign Patent References
International ClassesC07D 470/104A61K 031/435 Foreign Application Priority Data1986-12-02 FRAbstractPyrrole derivatives of formula (I): ##STR1## in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 2,3,6,7-tetrahydro-5H-[1,4]oxathiino[2,3-c]pyrrole or 2,3,6,7-tetrahydro-5H-[1,4]dithiino[2,3-c]pyrrole ring-system, Het=naphthyridinyl, pyridyl or quinolyl which are unsubstituted or substituted with halogen, (1 to 4 C) alkyl, (1 to 4 C) alkyloxy, (1 to 4 C) alkylthio or CF3, Y=CO, C=NOH or CHOH and R=(3 to 10 C) alkenyl, alkyl which is unsubstituted or substituted with OH, alkyloxy, alkylthio, (3 to 6 C) cycloalkyl, NH2, alkylamino, dialkylamino, alkylcarbonylamino, piperazinyl, piperidyl, 1-azetidinyl, morpholino, pyrrolidinyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, (1-piperazinyl)carbonyl, piperidinocarbonyl, pyrrolidinocarbonyl, phenyl, pyridyl, 1-imidazolyl or alternatively R=2- or 3-pyrrolididnyl, 2-, 3- or 4-piperidyl, (3 to 6 C) cycloalkyl or phenyl which is unsubstituted or substituted with halogen, (1 to 4 C) alkyl, (1 to 4 C) alkyloxy, (1 to 4 C) alkylthio, the said alkyl radicals and portions containing, except where specifically stated, 1 to 10 C, and the piperazinyl, piperidino, piperidyl, pyrrolidinyl, azetidinyl radicals being unsubstituted or substituted at any position by alkyl, alkylcarbonyl, benzyl or hydroxyalkyl, or can alternatively form a lactam group with the nitrogen atom of the ring, and their salts and optical isomers are useful as anxiolytics.Field of SearchThe other cyclo in the bicyclo ring system is also six-membered (e.g., naphthyridines, etc.)Chalcogen attached directly to the six-membered hetero ring by nonionic bonding Nitrogen, other than as nitro or nitroso, attached directly to the six membered hetero ring by nonionic bonding Nitrogen attached indirectly to the six-membered hetero ring through the directly attached nitrogen by nonionic bonding Plural hetero atoms in the bicyclo ring system Chalcogen attached directly to the six-membered hetero ring by nonionic bonding Nitrogen, other than as nitro or nitroso, attached directly to the six membered hetero ring by nonionic bonding Ring nitrogen in the polycyclo ring system |
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