Oxazolidinone penetration enhancing compounds
Patent 4960771 Issued on October 2, 1990. Estimated Expiration Date: 
July 12, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 12, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2909467 Penetration enhancers for transdermal drug delivery of systemic agents Vehicle composition containing 1-substituted azacyclohexan-2-ones Base composition for medicament and pharmaceutical composition for external medication Patent #: 4594243 InventorApplicationNo. 218316 filed on 07/12/1988US Classes:514/228.8, Hetero ring is six-membered and includes at least nitrogen and oxygen as ring hetero atoms (e.g., monocyclic 1,2- and 1,3-oxazines, etc.)514/376, Chalcogen bonded directly to ring carbon of the oxazole ring514/452, Plural ring oxygens in the hetero ring514/467, Only two ring oxygens in the hetero ring which is not a polycyclo ring system (e.g., dioxolane, etc.)514/470, Chalcogen or nitrogen bonded directly to the hetero ring514/947, Topical application544/318, Additional chalcogen attached directly or indirectly to the diazine ring by nonionic bonding548/229, Chalcogen bonded directly at 2-position of the oxazole ring548/230Nitrogen, halogen, or -C(=X)-, wherein X is chalcogen, attached directly to the oxazole ring by nonionic bondingExaminersPrimary: Schenkman, LeonardAttorney, Agent or FirmInternational ClassesA61K 031/42A61K 031/535 AbstractCompositions for carrying physiologically active agents through body membranes having the structural formula I: ##STR1## where: R=H, Alkyl group containing from 1-18 carbon atoms, cycloalkyl, aryl, aralkyl, alkoxy, hydroxyalkyl, alkoyloxyalkyl, acyloxyalkyl and alkoxyalkyl;X=O and NR1, where R1 is selected from H, alkyl, aralkyl acyl group containing from 1-18 carbon atoms, cycloalkyl, hydroxyalkyl, alkoyloxyalkyl acyloxyalkyl and alkoxyalkyl;Y=O and NR2, where R2 is selected from H, alkyl, aralkyl, cycloalkyl, acyl group containing from 1-18 carbon atoms, hydroxyalkyl, alkoyloxyalkyl, acyloxyalkyl and alkoxyalkyl;m=2-4; andn=0-4,are disclosed.Other References
Field of SearchChalcogen bonded directly to ring carbon of the oxazole ringTopical application Hetero ring is six-membered and includes at least nitrogen and oxygen as ring hetero atoms (e.g., monocyclic 1,2- and 1,3-oxazines, etc.) Plural ring oxygens in the hetero ring Only two ring oxygens in the hetero ring which is not a polycyclo ring system (e.g., dioxolane, etc.) |
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