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Protected complex of procaine for the treatment of symptoms from narcotics addiction, tinnitus and alzheimer's disease

Patent 4956391 Issued on September 11, 1990. Estimated Expiration Date: Icon_subject August 17, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2004891

2684323

Inventor

Application

No. 233247 filed on 08/17/1988

US Classes:

514/391, Benzene ring bonded directly to the diazole ring by nonionic bonding514/392, Divalent chalcogen or acyclic nitrogen double bonded at 2-position, or tautomeric equivalent514/471, Nitrogen containing514/535, The nitrogen of the Z radical is directly bonded to a benzene ring which is directly bonded to the C(=O) group514/540, Nitrogen in Y moiety514/812Narcotic

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Class

A61K 027/00

Abstract

The invention presented is a composition for the treatment of individuals addicted to narcotics or individuals having age-related condition such as tinnitus and Alzheimer's comprising a protected complex of procaine and a complexing agent for procaine in an amount effective to reduce the withdrawal symptoms of individuals addicted to narcotics or the symptoms of tinnitus and Alzheimer's disease.

Other References

  • Karpen, et al., "Cocaine, Phencyclidine, and Procaine Inhibition of the Acetylcholine Receptor: Characterization of the Binding Site by Stopped-Flow Measurements of Receptor-Controlled Ion Flux in Membrane Vesicles", Biochemistry 1986, 25, 1777-1785
  • Jarbe, "Discriminative Stimulus Properties of Cocaine" Neuropharmacology vol. 23, No. 8, pp. 899-907, 1984
  • Fischman, et al., "A Comparison of the Subjective and Cardiovascular Effects of Cocaine and Procaine in Humans", Pharm. Bio. & Beh., vol. 18, pp. 711-716, 1983
  • Garza, et al., "Effects of Haloperidol and Physostigmine on Self-Administration of Local Anesthetics", Pharm. Bio. & Beh., vol. 17, pp. 1295-1299, 1982
  • Johanson, et al., "Comparison of the Reinforcing Properties of Cocaine and Procaine in Rhesus Monkeys", Pharm. Bio. & Beh., vol. 15, pp. 49-53, 1981
  • Johanson, "The Reinforcing Properties of Procaine, Chloroprocaine and Proparacaine in Rhesus Monkeys", Psychopharmacology 67, 189-194, 1980
  • Gold, et al., "Clonidine Blocks Acute, Opiate-Withdrawal Symptoms", The Lancet, 1978, 599-601
  • Charney, et al., "Clonidine and Naltrexone, A Safe, Effective, and Rapid Treatment of Abrupt Withdrawal From Methadone Therapy", Arch Gen Psychiatry, vol. 39, 11/82
  • Kleber, et al., "Clonidine in Outpatient Detoxification From Methadone Maintenance", Arch Gen Psychiatry, vol. 42, 4/8
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