Patent 4944949 Issued on July 31, 1990. Estimated Expiration Date: December 17, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/455, Containing emulsions, dispersions, or solutions424/456, Gelatin514/825, ARTHRITIS514/937, DISPERSION OR EMULSION514/941Polyoxyalkylated compound containing
Non-steroidal anti-inflammatory drugs (NSAIDs) including diclofenac, flufenamic acid, flurbiprofen, ibuprofen, indomethacin, ketoprofen, naproxen, phenylbutazone, piroxicam and sulindac are administered in micelles to alleviate their adverse effects on the gastrointestinal tract. The drugs are formulated with surfactants such as polyethoxylated nonionics to give micelle-forming compositions.
Other References
Schott et al., The Role of Surfactants in the Release of Very Slightly Soluble Drugs from Tablets, 1982, 71 J. Pharm. Sci., 1038
Kim and Choe, Effect of Surfactants on the Solubility Properties of Indomethacin, 1984, 28 Yakhak Hoeji, 161
DT 2802-114 Chemical Abstracts
Chemical Abstracts DT 2902-672
Chemical Abstracts 104:193025j
Chemical Abstracts 104:135951x
Chemical Abstracts 104:10512y
Chemical Abstracts 103:183432c
Chemical Abstracts 101:975552
Chemical Abstracts 101:12070q
Chemical Abstracts 98:40512y
Chemical Abstracts 97:188287d
Chemical Abstracts 97:12252z
Chemical Abstracts 95:103216r
Chemical Abstracts 47718r
Chemical Abstracts 90:127464t
Chemical Abstracts 94:127260f
Chemical Abstracts 94:52772p
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Maher et al., "Structural Changes in Membranes Produced by Building of Small Amphipathic Molecules", Biochem., 1984, (23), 232-240
Chemical Abstracts 85:166564s; 104:155882d; 104:155883e; 108:192665p; 106:6723s; 94:52771