U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Pharmaceutical delivery systems

Patent 4944949 Issued on July 31, 1990. Estimated Expiration Date: Icon_subject December 17, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3887700

Means for administering amphipathic medicament
Patent #: 4182330
Issued on: 01/08/1980
Inventor: Michaels

Therapeutic compositions with enhanced bioavailability
Patent #: 4344934
Issued on: 08/17/1982
Inventor: Martin ,   et al.

Ibuprofen-containing soft gelatin capsules and process for preparing same Patent #: 4690823
Issued on: 09/01/1987
Inventor: Lohner ,   et al.

Inventors

Assignee

Application

No. 134243 filed on 12/17/1987

US Classes:

424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/455, Containing emulsions, dispersions, or solutions424/456, Gelatin514/825, ARTHRITIS514/937, DISPERSION OR EMULSION514/941Polyoxyalkylated compound containing

Examiners

Primary: Chaudhuri, Olik
Assistant: Griffis, Andrew

Attorney, Agent or Firm

Foreign Patent References

  • 1601613 GB2. 11/13/1981
  • 0102324 EP. 07/13/1983
  • 0101294 EP. 02/13/1984
  • 0178436 EP. 04/13/1986
  • 0179583 EP. 04/13/1986
  • 0223369 EP. 05/13/1987
  • 3315805 DE. 11/13/1984
  • 9010524 JP. 01/13/1984
  • 148718 JP. 08/13/1984
  • 8602264 WO. 04/13/1986
  • 8603675 WO. 07/13/1986

International Class

A61K 009/66

Foreign Application Priority Data

1986-12-18 GB

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) including diclofenac, flufenamic acid, flurbiprofen, ibuprofen, indomethacin, ketoprofen, naproxen, phenylbutazone, piroxicam and sulindac are administered in micelles to alleviate their adverse effects on the gastrointestinal tract. The drugs are formulated with surfactants such as polyethoxylated nonionics to give micelle-forming compositions.

Other References

  • Schott et al., The Role of Surfactants in the Release of Very Slightly Soluble Drugs from Tablets, 1982, 71 J. Pharm. Sci., 1038
  • Kim and Choe, Effect of Surfactants on the Solubility Properties of Indomethacin, 1984, 28 Yakhak Hoeji, 161
  • DT 2802-114 Chemical Abstracts
  • Chemical Abstracts DT 2902-672
  • Chemical Abstracts 104:193025j
  • Chemical Abstracts 104:135951x
  • Chemical Abstracts 104:10512y
  • Chemical Abstracts 103:183432c
  • Chemical Abstracts 101:975552
  • Chemical Abstracts 101:12070q
  • Chemical Abstracts 98:40512y
  • Chemical Abstracts 97:188287d
  • Chemical Abstracts 97:12252z
  • Chemical Abstracts 95:103216r
  • Chemical Abstracts 47718r
  • Chemical Abstracts 90:127464t
  • Chemical Abstracts 94:127260f
  • Chemical Abstracts 94:52772p
  • Miyazaki et al., "Micellar Interaction of Indomethacin and Phenylbutazone with Bile Salts", Int. J. Parm 8, (1981), 303-310
  • Paradies, H. "Structure of Phenylbutazone and Mofebutazone in the Crystalline State and in Solution", J. Pharm Sci., 76(12), 920-929
  • Maher et al., "Structural Changes in Membranes Produced by Building of Small Amphipathic Molecules", Biochem., 1984, (23), 232-240
  • Chemical Abstracts 85:166564s; 104:155882d; 104:155883e; 108:192665p; 106:6723s; 94:52771
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