Controlled release powder and process for its preparation

Patent 4940588 Issued on July 10, 1990. Estimated Expiration Date:

March 17, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

Elan Corporation, plc

Application

No. 171131 filed on 03/17/1988

US Classes:

424/490, Coated (e.g., microcapsules)424/48, CHEWING GUM TYPE424/440, Candy, candy coated or chewing gum424/441, Chewable tablet or wafer424/464, Tablets, lozenges, or pills424/469, Discrete particles in supporting matrix424/470, Where particles are granulated424/484, Matrices424/486, Synthetic polymer424/487, Acrylic acid and derivatives424/488, Polysaccharides (e.g., cellulose, etc.)424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/494, Cellulose derivatives424/497Containing solid synthetic polymers

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

Falk; Robert H., Croskell; Henry

Foreign Patent References

873815 CA. 06/13/1971
1025359 CA 05/13/1973
1142810 CA 03/13/1983
0002574 EP. 01/13/1978
0094513 EP. 04/13/1983
8300284 WO. 07/13/1982
1056259 GB. 01/13/1967
1205769 GB. 09/13/1970
1287431 GB. 08/13/1972
1478947 GB. 07/13/1977
1569036 GB. 06/13/1980
2059764 GB. 09/13/1980
2017624B GB. 07/13/1982
2147501A GB. 09/13/1985

International Classes

A61K 009/14
A61K 009/16

Foreign Application Priority Data

1984-10-30 IE

Abstract

A controlled release powder containing discrete micro-particles for use in edible, pharmaceutical and other controlled release compositions is disclosed. The micro-particles have an average size in the range of from 0.1 to 125 μm. Each of the micro-particles is in the form of a micromatrix of an active ingredient uniformly distributed in at least one non-toxic polymer. The micro-particles have a predetermined release of active ingredient when the dissolution rate thereof is measured according to the Paddle Method of U.S. Pharmacopoeia XX at 37° C. and 75 r.p.m.

Other References

Beck et al., "A New Long-Acting Injectable Microcapsule System . . . ", Fertility and Sterility, vol. 31, No. 5, May 1979, pp. 545-551
Fong et al., "Evaluation of Biodegradable Microspheres Prepared by a Solvent Evaporation Process . . . ", J. of Controlled Release, 3 (1986), 119-13