U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method for inhibiting post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug

Patent 4937254 Issued on June 26, 1990. Estimated Expiration Date: Icon_subject January 26, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventors

Assignee

Application

No. 148464 filed on 01/26/1988

US Classes:

424/497, Containing solid synthetic polymers424/78.05, Anti-inflammatory or anti-irritant (e.g., anti-arthritic, etc.)514/420, Indomethacine per se or ester thereof514/423, C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)514/576Benzene ring containing

Examiners

Primary: Nutter, Nathan M.

International Class

A61K 031/74

Abstract

Postsurgical adhesion formation is inhibited by the topical administration to the site of surgical trauma of a non-steroidal anti-inflammatory drug, preferably ibuprofen, suprofen, or tolmetin.

Other References

  • Stangel et al., "Formation and Prevention of Postoperative Abdominal Adhesions", J. of Repro. Med., vol. 29, No. 3, Mar., 1984, pp. 143-156
  • "The Cause and Prevention of Postsurgical Adhesions", diZerega, Pregnancy Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 18, Rm. 101, Bethesda, MD 20205
  • "Ibuprofen Inhibition of Postsurgical Adhesion Formation: A Time and Dose Response Biochemical Evaluation in Rabbits", Nishimura, Nakamura, and diZerega, Journal of Surgical Research 36, 115-124, Feb., 1984
  • "Prevention of Postoperative Adhesions in Rabbits with Ibuprofen, A Nonsteroidal Anti-Inflammatory Agent", Siegler et al., Fertility and Sterility 34, No. 1, pp. 46-49, Jul., 1980
  • "Prevention of Postoperative Peritoneal Adhesions with Ibuprofen", Bateman et al., Fertility and Sterility 38, No. 1, pp. 107-108, Jul., 1982
  • "Oxyphenbutazone--Anti-Inflammatory Agent--in Prevention of Peritoneal Adhesions", Kapur et al., Arch Surg 98, pp. 301-302, Mar., 1969
  • "The Use of Ibuprofen and Dexamethasone in the Prevention of Postoperative Adhesion Formation", O'Brien, Obstetrics & Gynecology 60, No. 3, pp. 373-378, Sep., 1982
  • "Biochemical Evaluation of Postsurgical Wound Repair: Prevention of Intraperitoneal Adhesion Formation with Ibuprofen", Nishimura et al., Journal of Surgical Research 34, pp. 219-226, 1983
  • "The Carrier Potential of Liposomes in Biology and Medicine", New England Journal of Medicine, vol. 295, pp. 704-710 and pp. 765-770, Sep. 23 and 30, 197
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