U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Liposomal local anesthetic and analgesic products

Patent 4937078 Issued on June 26, 1990. Estimated Expiration Date: Icon_subject August 26, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3645911

3804776

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Patent #: 4016100
Issued on: 04/05/1977
Inventor: Suzuki ,   et al.

Topical steroid formulation in form of lotion or cream
Patent #: 4048310
Issued on: 09/13/1977
Inventor: Chen, et al.

Process for the preparation of liposomes
Patent #: 4089801
Issued on: 05/16/1978
Inventor: Schneider

Method of encapsulating biologically active materials in lipid vesicles
Patent #: 4235871
Issued on: 11/25/1980
Inventor: Papahadjopoulos ,   et al.

Immunoassay products and methods
Patent #: 4342826
Issued on: 08/03/1982
Inventor: Cole

Process and device for producing bilayer vesicles
Patent #: 4438052
Issued on: 03/20/1984
Inventor: Weder ,   et al.

Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
Patent #: 4485054
Issued on: 11/27/1984
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Method of preparing giant size liposomes
Patent #: 4532089
Issued on: 07/30/1985
Inventor: MacDonald

More ...

Inventors

Assignee

Application

No. 236724 filed on 08/26/1988

US Classes:

424/450, Liposomes514/817, ANESTHETIC, TOPICAL514/818ANESTHETIC, LOCAL

Examiners

Primary: Robinson, Ellis P.
Assistant: Prater, P. L.

Attorney, Agent or Firm

Foreign Patent References

  • 00084898 EP. 08/13/1983
  • 3335701A1 DE. 04/13/1981
  • WO85/03640 WO. 08/13/1985
  • 2050833A GB. 01/13/1981

International Class

A61K 037/22

Abstract

Liposome encapsulated local anesthetic or analgesic agents when applied to skin or mucous membranes provided greater local anesthesia and analgesia than the same agents incorporated in conventional vehicles i.e., ointment, cream or lotion.

Other References

  • Bangham et al., "Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids", J. Mol. Biol. 13:238-252 (1965)
  • Bangham et al., "Osmotic Properties and Water Permeability of Phospholipid Lipid Crystals, Chem. Phys. Lipids, 1:225-246 (1967)
  • Batzri et al., "Single Bilayer Liposomes Prepared Without Sonication", Biochim. et Biophys. Acta, 298:1015-1019
  • Bangham et al., "Preparation and Use of Liposomes as Models of Biological Membranes", Methods in Membrane Biology, 6 (London 1974)
  • Papahadjopoulos et al, "Effects of Local Anesthetics on Membrane Properties", Biochim et Biophys. Acta, 394:504-519 (1975)
  • Theoharides, "Liposomes as Carriers of Biologically Active Molecules", Folia Bioch. et Biol. Graeca, Special Issue, vol. XIV, pp. 11-21 (1978)
  • Mezei et al., "Liposomes-A Selective Drug Delivery System for the Topical Route of Administration", Life Sciences, vol. 26, pp. 1473-1477 (1980)
  • Okano et al., "Duration of the Local Anesthetic Action of Dibucaine by Liposomes and Its Mechanism", Yakugaku Zasshi, vol. 100 (11), pp. 1097-1103 (1980)
  • Chemical Abstracts, vol. 97, No. 22 (1982), Abstract No. 188156k
  • "The Effect of Local Anaesthetics on the Osmotic Fragility of Liposomes", Biochemical Pharmacology, vol. 31, No. 18, pp. 2999-3000 (1982)
  • Mezei et al., "Liposomes--A Selective Drug Delivery System for the Topical Route of Administration: Gel Dosage Form", J. Pharm. Pharmacol., 1982, 34:473-474
  • Cecil-"Textbook of Medicine", vol. 1 (1982), pp. 1276-1278
  • Seelig, Biochimica et Biophysica Acta 899 (1987) 196-204
  • Kuroda et al., Biochimica et Biophysica Acta 903 (1987) 395-410
  • Bianconi et al., Biochemical and Biophysical Research Communications, vol. 152(1):344-350 (1988)
  • Seelig et al., Biochimica et Biophysica Acta 939 (1988) 267-276
  • Gesztes et al., Topical Anesthesia of the Skin by Liposome-Encapsulated Tetracaine, Anesth Analg, vol. 67:1079-1081 (1988)
  • Mezei, "Liposomes in the Topical Application of Drugs: a Review", Liposomes as Drug Carriers, edited by G. Gregoriadis, John Wiley & Sons Ltd., NY (1988) pp. 663-677
  • Ohki, Biochimica et Biophysica Acta, 777 (1984) 56-66
  • Schlieper et al., Biochemical Pharmacology, vol. 32, No. 5, pp. 799-804 (1983)
  • Simmonds et al., Biochimica et Biophysica Acta, 813 (1985) 331-337
  • Krause-Friedmann et al., Biochimica et Biophysica Acta, 799 (1984) 195-198
  • Dalili et al. Clin. Pharm. Ther., 12:9-919 (1971)
  • Adriani et al., Anesth. Analg., 50:834-841 (1971)
  • Juhlin et al., Acta Dermatovener 59:556-559 (1979)
  • Wildsmith et al., Clinics in Anaesthesiology, 4:527-537 (1986)
  • Ehrenstrom Reiz et al., Acta Anaesth. Scand. 26:596-598 (1982)
  • Evers et al., Br. J. Anaesth. 58:997-1005 (1985)
  • Juhlin et al., Acta Dermatovener 60:544-546 (1980
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