Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity
Patent 4933326 Issued on June 12, 1990. Estimated Expiration Date: 
September 21, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 21, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHeparin fragments having selective anticoagulation activity Anticoagulant substance Mucopolysaccharides having biological properties, preparation and method of use Patent #: 4500519 InventorsAssigneeApplicationNo. 247154 filed on 09/21/1988US Classes:514/56, Heparin or derivative514/822, ANTICOAGULATION536/21Heparin or derivativeExaminersPrimary: Rollins, John W.Attorney, Agent or FirmInternational ClassesA61K 031/725C08B 037/10 Foreign Application Priority Data1983-03-08 ITAbstractHeparin fractions which are a mixture of oligosaccharides containing 6-12 monosaccharides are described. The oligosaccharides contain reducing end groups composed of iduronic acid 2-sulfate or glucosamine N, 6-disulfate. The end group monosaccharides contain the reducing anomeric carbons. The SO3- /COO- ratio is essentially the same as in heparin. The method of preparation is a depolymerization initiated by free radicals. One fraction is a heparin fragment with a molecular weight (MWw) of 2,100 daltons (+10%). The compound contains 6-8 monosaccharides, has the same SO3- /COO- ratio as the parent heparin and has platelet anti-aggregating activity, arterial and venous antithrombotic action, fibrinolytic and antiatherosclerotic activity. It exhibits poor anti factor Xa activity and no anticoagulant action. |
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