Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
Patent 4931464 Issued on June 5, 1990. Estimated Expiration Date: 
February 15, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 15, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMercaptoacyl derivatives of substituted prolines Phosphinylalkanoyl substituted prolines Phosphinylalkanoyl substituted prolines Orally active phosphonyl hydroxyacyl prolines Pharmaceutical compositions in the form of beadlets and method Patent #: 4808413 InventorsAssigneeApplicationNo. 311321 filed on 02/15/1989US Classes:514/423C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)ExaminersPrimary: Gerstl, RobertAttorney, Agent or FirmInternational ClassA61K 031/40AbstractZofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-oxohexyl]-L-proli ne or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre- and post- ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.Other References
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