Patent ReferencesAzetidine-2-carboxylic acid derivatives Derivatives of mercaptoacyl prolines and pipecolic acids Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines Mercaptoacyl derivatives of substituted prolines Phosphinylalkanoyl substituted prolines Substituted phosphonamides as antihypertensives Substituted carbonyl phosphinyl-alkanoyl compounds Pharmaceutical amides, and preparation, formulations and use of thereof Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives Pharmaceutical amides, and preparation, formulations and use thereof InventorsAssigneeApplicationNo. 270872 filed on 11/14/1988US Classes:514/19, 2 peptide repeating units in known peptide chain514/7, Phosphorus containing514/89, Hetero ring is six-membered and includes only one ring nitrogen514/91, Hetero ring is five-membered514/92, Two or more hetero atoms in the five-membered ring514/94, Diazoles (including hydrogenated)514/171, With additional active ingredient514/211.07, Nitrogen attached directly or indirectly to the ring nitrogen of the seven-membered hetero ring by acyclic nonionic bonding (e.g., Diltiazem, etc.)514/218, Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms514/223.5, With additional active ingredient514/249, 1,4-diazine as one of the cyclos514/253.13, Having -C(=X)-, wherein X is chalcogen, bonded directly to the additional six-membered nitrogen hetero ring514/278, Spiro ring system514/318, The additional ring is a six-membered hetero ring consisting of one nitrogen and five carbon atoms514/338, Plural hetero atoms in the polycyclo ring system514/343, The additional hetero ring consists of one nitrogen and four carbons (e.g., nicotine, etc.)514/409, Spiro ring system514/422, Additional hetero ring514/423, C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)514/616, Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen514/693Aldehyde DOAIExaminersPrimary: Lee, Lester L.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 037/02C07K 005/06 693 AbstractA method is provided for inhibiting onset of or treating anxiety by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or SQ 29,852, alone or in combination with a calcium channel blocker such as diltiazem or nifedipine, over a prolonged period of treatment.Other References
Field of SearchPhosphorus containing2 peptide repeating units in known peptide chain Hetero ring is six-membered and includes only one ring nitrogen Hetero ring is five-membered Two or more hetero atoms in the five-membered ring Diazoles (including hydrogenated) With additional active ingredient Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms With additional active ingredient 1,4-diazine as one of the cyclos Spiro ring system The additional ring is a six-membered hetero ring consisting of one nitrogen and five carbon atoms Plural hetero atoms in the polycyclo ring system The additional hetero ring consists of one nitrogen and four carbons (e.g., nicotine, etc.) Spiro ring system Additional hetero ring C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen) Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen Phosphorus attached indirectly to the five-membered hetero ring by nonionic bonding | |