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Method for preventing or treating anxiety employing an ACE inhibitor

Patent 4931430 Issued on June 5, 1990. Estimated Expiration Date: Icon_subject November 14, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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Inventors

Assignee

Application

No. 270872 filed on 11/14/1988

US Classes:

514/19, 2 peptide repeating units in known peptide chain514/7, Phosphorus containing514/89, Hetero ring is six-membered and includes only one ring nitrogen514/91, Hetero ring is five-membered514/92, Two or more hetero atoms in the five-membered ring514/94, Diazoles (including hydrogenated)514/171, With additional active ingredient514/211.07, Nitrogen attached directly or indirectly to the ring nitrogen of the seven-membered hetero ring by acyclic nonionic bonding (e.g., Diltiazem, etc.)514/218, Hetero ring is seven-membered consisting of two nitrogens and five carbon atoms514/223.5, With additional active ingredient514/249, 1,4-diazine as one of the cyclos514/253.13, Having -C(=X)-, wherein X is chalcogen, bonded directly to the additional six-membered nitrogen hetero ring514/278, Spiro ring system514/318, The additional ring is a six-membered hetero ring consisting of one nitrogen and five carbon atoms514/338, Plural hetero atoms in the polycyclo ring system514/343, The additional hetero ring consists of one nitrogen and four carbons (e.g., nicotine, etc.)514/409, Spiro ring system514/422, Additional hetero ring514/423, C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)514/616, Plural carboxamide groups or plural C=O groups bonded directly to the same nitrogen514/693Aldehyde DOAI

Examiners

Primary: Lee, Lester L.

Attorney, Agent or Firm

Foreign Patent References

  • 361039 DE 10/12/1987

International Classes

A61K 037/02
C07K 005/06
693

Abstract

A method is provided for inhibiting onset of or treating anxiety by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or SQ 29,852, alone or in combination with a calcium channel blocker such as diltiazem or nifedipine, over a prolonged period of treatment.

Other References

  • "Angiotensin Converting Enzyme Inhibitors: Animal Experiments Suggest a New Pharmacological Treatment for Alcohol Abuse in Humans", G. Spinosa et al, Alcoholism: Clinical and Experimental Research, vol. 12, No. 1, Jan./Feb. 1988, pp. 65-70
  • S. J. Dolin et al, "Calcium Channel Antagonists Decrease the Ethanol Withdrawal Syndrome" British Journal of Pharm., vol. 87, Mar. Suppl. 40P (1986)
  • Qin Wencai et al, "Nimodipine, Nifedipine and Vincamine Improve Amnesia Induced by Anisodine and Sodium Nitrite in Rats and Mice" Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao, Oct. 1986, 8(5), pp. 366-370
  • S. H. Croog et al, "The Effects of Antihypertensive Therapy on the Quality of Life" New Engl. J. of Med., 314:1657-1664 (6/26/86
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