U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Method for preventing or treating depression employing an ace inhibitor

Patent 4912096 Issued on March 27, 1990. Estimated Expiration Date: Icon_subject June 26, 2009. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Assignee

Application

No. 371161 filed on 06/26/1989

US Classes:

514/91, Hetero ring is five-membered514/422, Additional hetero ring514/423C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Classes

A61K 031/40
A61K 031/675

Abstract

A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1-oxohexyl]-L-pr oline, fosinopril or zofenopril, alone or in combination with an antidepressant drug such as lithium, over a prolonged period of treatment.

Other References

  • Deicken, R. F., "Captopril Treatment of Depression", Biol. Psychiatry, 1986; 21:1425-1428
  • Zubenko, G. S., "Mood-Elevating Effect of Captopril in Depressed Patients", Am. J. Psychicatry 141: 110-11, 1984
  • Germain, L. et al., "Treatment of Recurrent Unipolar Major Depression with Captopril", Biol. Psychiatry, 1988; 23:637-641
  • Giardina, W. J. et al., "Positive Effects of Captopril in the Behavioral Despair Swim Test", Biol. Psychiatry 1989; 25:695-702
  • Bosio, A. et al., "Antidepressant Activity of ACE-Inhibitors", TIPS, vol. 8, pp. 329-330, 1987 (Abstracts of 141st Annual Meeting of the American Psychiatric Assoc., Montreal, Canada, May 7-12, 1988
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
PatentsPlus: add to cart
PatentsPlus: add to cartIntelligent turbocharged patent PDFs with marked up images
$18.95more info
 
Sign InRegister
Username  
Password   
forgot password?