U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Steroid 5-alpha-reductase inhibitors

Patent 4910226 Issued on March 20, 1990. Estimated Expiration Date: Icon_subject December 1, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3530170

Novel steroid 5଱-reductase inhibitors Patent #: 4317817
Issued on: 03/02/1982
Inventor: Blohm ,   et al.

Inventors

Application

No. 127147 filed on 12/01/1987

US Classes:

514/573, Cyclopentyl or cyclopentene (e.g., prostaglandins, etc.)514/319, The additional ring is one of the cyclos in a polycyclo ring system514/428, Chalcogen bonded indirectly to the five-membered hetero ring by acyclic nonionic bonding514/462, Spiro ring system514/510, Polycyclo ring system546/195, The additional ring is one of the cyclos in a polycyclo ring system548/253, The chalcogen, X, is in a -C(=X)- group548/528, Polycyclo carbocyclic ring system having at least three cyclos549/331, The spiro includes a hetero ring549/499, The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens560/116, Plural alicyclic rings in acid moiety560/162Cyclic alcohol moiety

Examiners

Primary: Sneed, Helen M. S.
Assistant: Saba, J.

Attorney, Agent or Firm

International Classes

C07C 069/74
C07C 125/06
C07D 251/40
C07D 432/00

Abstract

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-଱-reductase. Also invented are intermediates used in preparing these compounds.

Other References

  • A useful synthesis of A-nor-Ɗ35 Steroids by Thallium Trinitnate Ring, A Cotraction of Ɗ4-5 -3-Keto steroids Enrico et al. Chemical Asst. 94:209060 (1981
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