Patent 4910226 Issued on March 20, 1990. Estimated Expiration Date: December 1, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
514/573, Cyclopentyl or cyclopentene (e.g., prostaglandins, etc.)514/319, The additional ring is one of the cyclos in a polycyclo ring system514/428, Chalcogen bonded indirectly to the five-membered hetero ring by acyclic nonionic bonding514/462, Spiro ring system514/510, Polycyclo ring system546/195, The additional ring is one of the cyclos in a polycyclo ring system548/253, The chalcogen, X, is in a -C(=X)- group548/528, Polycyclo carbocyclic ring system having at least three cyclos549/331, The spiro includes a hetero ring549/499, The -C(=X)- is part of a -C(=X)X- group, wherein the X's are the same or diverse chalcogens560/116, Plural alicyclic rings in acid moiety560/162Cyclic alcohol moiety
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5--reductase. Also invented are intermediates used in preparing these compounds.
Other References
A useful synthesis of A-nor-Ɗ35 Steroids by Thallium Trinitnate Ring, A Cotraction of Ɗ4-5 -3-Keto steroids Enrico et al. Chemical Asst. 94:209060 (1981