Ethanolamine derivatives
Patent 4908386 Issued on March 13, 1990. Estimated Expiration Date: 
December 20, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 20, 2008. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3818101 Bronchospasmolytic phenylethanolamines Phenethylamine derivatives and bronchdilator containing the same Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols Aminophenol derivatives Patent #: 4730008 Inventors
AssigneeApplicationNo. 287441 filed on 12/20/1988US Classes:514/608, Sulfur attached directly to amino nitrogen by nonionic bonding (e.g., sulfenamides, etc.)514/227.5, 1,4-Thiazines514/227.8, Additional hetero ring attached directly or indirectly to the 1,4-thiazine by nonionic bonding514/231.2, Morpholines (i.e., fully hydrogenated 1,4- oxazines)514/235.5, Ring nitrogen in the additional hetero ring514/239.5, Carbocyclic ring attached indirectly to the morpholine ring by nonionic bonding514/253.12, Chalcogen bonded directly to ring carbon of the additional six-membered nitrogen containing hetero ring514/255.03, Carbocyclic ring bonded directly to the piperazine ring514/330, C=X bonded directly to the piperidine ring (X is chalcogen)514/331, Nitrogen attached indirectly to the piperidine ring by nonionic bonding514/423, C=X bonded directly to the five-membered hetero ring by nonionic bonding (X is chalcogen)514/428, Chalcogen bonded indirectly to the five-membered hetero ring by acyclic nonionic bonding514/456, Bicyclo ring system having the hetero ring as one of the cyclos (e.g., chromones, etc.)514/466, Nitrogen containing514/484, Ring in acid moiety514/487, The benzene ring is attached to nitrogen through an acyclic carbon or carbon chain514/522, The cyano is bonded directly to a benzene ring514/523, Additional nitrogen other than cyano514/524, The cyano is bonded directly to a benzene ring514/539, Plural separated benzene rings in Z moiety514/562, Sulfur nonionically bonded514/563, RC(=O)N containing (i.e., carboxamide) (R is C or H)514/564, Plural nitrogens nonionically bonded514/565, N-N or N=C(-N)-N containing (e.g., hydrazines, hydrazones, or quanidines, etc.)514/595, Benzene ring containing514/597, Benzene ring is part of a substituent which contains nitrogen514/600, Sulfamides (i.e., N-(O=)S(=O)-N)514/629, R is hydrogen or a lower saturated alkyl of less than seven carbons514/649, Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain514/651, Ether oxygen is part of the chain514/718, Plural oxygens514/826, ASTHMA544/59, Thiomorpholines (i.e., fully hydrogenated 1,4-thiazines)544/159, Nitrogen attached directly or indirectly to morpholine ring by nonionic bonding544/165, Carbocyclic ring bonded directly to the nitrogen544/398, Chalcogen attached indirectly to the piperazine ring by nonionic bonding544/400, Acyclic nitrogen bonded directly to the -C(=X)- group546/221, Having -C(=X)-, wherein X is chalogen, attached directly or indirectly to the piperidine ring by nonionic bonding546/226, At 1-position546/232, Chalcogen attached indirectly to the piperidine ring by nonionic bonding546/234, Plural carbocyclic rings containing546/235, The chalcogen, X, is in a -C(=X)- group548/567, The nitrogen is bonded directly to -C(=X)-, wherein X is chalcogen (e.g., 2 benzamidomethyl - pyrrolidines, etc.)548/569, The nitrogen is in a substituent attached to the ring nitrogen of the five membered hetero ring548/577, Benzene ring bonded directly to the five-membered hetero ring549/365, The ring oxygens are in the 1,2- or 1,3-positions of the hetero ring549/408, Chalcogen bonded directly to the carbocyclic ring of the bicyclo ring system (e.g., tocopherols, etc.)549/441, The nitrogen is bonded directly to a -C(=X)- group, wherein X is chalcogen549/443, Chalcogen attached indirectly to the bicyclo ring system by nonionic bonding558/408, Nitrogen, except as nitro or nitroso, attached indirectly to the cyano group by nonionic bonding558/413, Sulfur, double bonded to oxygen, attached indirectly to the cyano group by nonionic bonding558/414, Carbonyl attached indirectly to the cyano group by nonionic bonding558/422, The nitrogen is attached indirectly to a benzene ring by acyclic nonionic bonding560/13, Plural nitrogens in acid moiety560/27, Plural rings in acid moiety560/34, Ureido, guanido or hydrazino in acid moiety560/42, Oxy in acid moiety562/430, Nitrogen562/434, Nitro or nitroso562/452, Oxy564/49, The benzene ring is part of a substituent which contains sulfur564/50, The benzene ring is part of a substituent which contains nitrogen564/51, The substituent nitrogen is attached indirectly to the benzene ring by acyclic nonionic bonding564/56, Aralkyl bonded directly to urea nitrogen564/79, Sulfamides (i.e., HNH-(O=)S(=O)-HNH, wherein substitution may be made for hydrogen only)564/99, Benzene ring in a substituent E564/220, Amino nitrogen in the substituent E (i.e.,plural amino nitrogens containing)564/363, Beta hydroxy phenethylamines (i.e., hydroxy and the benzene ring are bonded directly to the same carbon of the chain which consists of two carbons; H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)564/369Mono ethylene diaminesExaminersPrimary: Raymond, Richard L.Assistant: Covington, Raymond Foreign Patent References
International ClassesC07C 143/74A61K 031/18 Foreign Application Priority Data1985-10-15 GBAbstractThe present invention provides compounds of general formula (I) ##STR1## wherein Ar represents an unsubstituted or substituted phenyl gorup;R1 and R2 each represents a hydrogen atom or a C1-3 alkyl group;X represents a bond or a C1-7 alkylene, C2-7 alkenylene or C2-7 alkynylene chain;Y represents a bond or a C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene chain;Q represents a substituted phenyl or pyridyl ring;and physiologically acceptable salts and solvates thereof useful as stimulants of 2 -adrenoreceptors and particularly in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.Field of SearchBenzene ring bonded directly to the five-membered hetero ringThe nitrogen is bonded directly to -C(=X)-, wherein X is chalcogen (e.g., 2 benzamidomethyl - pyrrolidines, etc.) The nitrogen is in a substituent attached to the ring nitrogen of the five membered hetero ring Plural carbocyclic rings containing Chalcogen attached indirectly to the piperidine ring by nonionic bonding Having -C(=X)-, wherein X is chalogen, attached directly or indirectly to the piperidine ring by nonionic bonding At 1-position Acyclic nitrogen bonded directly to a -C(=X)- group, wherein X is chalcogen ASTHMA Ether oxygen is part of the chain Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain Plural oxygens Beta hydroxy phenethylamines (i.e., hydroxy and the benzene ring are bonded directly to the same carbon of the chain which consists of two carbons; H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) Mono ethylene diamines Thiomorpholines (i.e., fully hydrogenated 1,4-thiazines) Nitrogen attached directly or indirectly to morpholine ring by nonionic bonding Carbocyclic ring bonded directly to the nitrogen Nitrogen attached directly to the phenazine ring system by nonionic bonding Acyclic nitrogen bonded directly to the -C(=X)- group Having -C(=X)-, wherein X is chalcogen, bonded directly to ring carbon of the additional six-membered hetero ring (e.g., nicotinic acid, etc.) Nitrogen, except as nitro or nitroso, attached indirectly to the cyano group by nonionic bonding Sulfur, double bonded to oxygen, attached indirectly to the cyano group by nonionic bonding Carbonyl attached indirectly to the cyano group by nonionic bonding The nitrogen is attached indirectly to a benzene ring by acyclic nonionic bonding |
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